791593-72-1Relevant academic research and scientific papers
ANTIBODY DRUG CONJUGATES (ADCS) WITH NAMPT INHIBITORS
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Page/Page column 325-326, (2021/01/29)
Conjugate of a binder having formula (AA) wherein AB stands for a binder, Z' stands for a linker, D stands for an active component which is a NAMPT inhibitor and its use as pharmaceuticals.
DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS
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Page/Page column 223; 224, (2018/05/27)
Compounds of formula (I) which are nicotinamide phosphoribosyltransferase (NAMPT) inhibitors and their use for the treatment of hyperproloferative diseases and/or disorders responsive to induction of cell death.
Iridium-Catalyzed Asymmetric Hydrogenation of β,γ-Unsaturated γ-Lactams: Scope and Mechanistic Studies
Yuan, Qianjia,Liu, Delong,Zhang, Wanbin
supporting information, p. 1144 - 1147 (2017/03/14)
An efficient asymmetric hydrogenation of β,γ-unsaturated γ-lactams using an iridium-phosphoramidite complex is reported. The chiral γ-lactams were obtained in excellent yields and enantioselectivities (up to 99% yield and 99% ee). The mechanistic studies
Novel inhibitors of 17β-hydroxysteroid dehydrogenase type 1: Templates for design
Allan, Gillian M.,Vicker, Nigel,Lawrence, Harshani R.,Tutill, Helena J.,Day, Joanna M.,Huchet, Marion,Ferrandis, Eric,Reed, Michael J.,Purohit, Atul,Potter, Barry V.L.
, p. 4438 - 4456 (2008/09/21)
The 17β-hydroxysteroid dehydrogenases (17β-HSDs) catalyze the interconversion between the oxidized and reduced forms of androgens and estrogens at the 17 position. The 17β-HSD type 1 enzyme (17β-HSD1) catalyzes the reduction of estrone (E1) to estradiol a
Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
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Page 12, (2008/06/13)
This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
