791603-32-2Relevant articles and documents
Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors
De La Fuente, Alex,Mena-Barragán, Teresa,Farrar-Tobar, Ronald A.,Verdaguer, Xavier,García Fernández, José M.,Ortiz Mellet, Carmen,Riera, Antoni
, p. 6500 - 6510 (2015/06/16)
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic potential for the treatment of various diseases, including several lysosomal storage disorders. A stereoselective synthesis of 2-
General approach to glycosidase inhibitors. Enantioselective synthesis of deoxymannojirimycin and swainsonine
Martin, Ruben,Murruzzu, Caterina,Pericas, Miquel A.,Riera, Antoni
, p. 2325 - 2328 (2007/10/03)
(Chemical Equation Presented) Deoxymannojirimycin (2) and swainsonine (4) have been synthesized from each enantiomer of the same bicyclic carbarnate precursor 7. The key intermediate was prepared by a simple and efficient three-step synthesis involving RCM of the diene 8, which in turn is easily accessible in any configuration from enantiomerically enriched 2,3-epoxy-4-penten-1-ol 9.
Synthesis and biochemical properties of reversible inhibitors of UDP-N-acetylglucosamine 2-epimerase
Al-Rawi, Samy,Hinderlich, Stephan,Reutter, Werner,Giannis, Athanassios
, p. 4366 - 4370 (2007/10/03)
Sialic acids have important biochemical functions in healthy organisms, for example, in embryogenesis, as well as in the spread of diseases like influenza. A key step in the biosynthesis of the sialic acid N-acetylneuraminic acid is the epimerization of 1