791619-80-2

Basic information

• Product Name: 3,5-Pyridinedicarbonitrile, 2-amino-4-[4-(difluoromethoxy)phenyl]-6-(phenylthio)-
• CAS NO: 791619-80-2
• Molecular Formula: C20H12F2N4OS
• Molecular Weight: 394.404
• Mol File: 791619-80-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarbonitrile, 2-amino-4-[4-(difluoromethoxy)phenyl]-6-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarbonitrile, 2-amino-4-[4-(difluoromethoxy)phenyl]-6-(phenylthio)-(791619-80-2)
• EPA Substance Registry System: 3,5-Pyridinedicarbonitrile, 2-amino-4-[4-(difluoromethoxy)phenyl]-6-(phenylthio)-(791619-80-2)

Safety Data

• Hazardous Substances Data: 791619-80-2(Hazardous Substances Data)

Upstream product

• 304685-68-5 2-(4-difluoromethoxybenzylidene)malononitrile 
• 108-98-5 thiophenol 
• 109-77-3 malononitrile 
• 73960-07-3 4-difluoromethoxybenzaldehyde 

Downstream Products

• 791619-88-0 2-amino-4-(4-difluoromethoxyphenyl)-6-mercaptopyridine-3,5-dicarbonitrile 

Relevant articles and documents

A series of ligands displaying a remarkable agonistic-antagonistic profile at the adenosine A1 receptor

Adenosine receptor agonists are usually variations of the natural ligand, adenosine. The ribose moiety in the ligand has previously been shown to be of great importance for the agonistic effects of the compound. In this paper, we present a series of nonadenosine ligands selective for the adenosine A 1 receptor with an extraordinary pharmacological profile. 2-Amino-4-benzo-[1,3]dioxol-5-yl-6-(2-hydroxyethylsulfanyl)pyridine-3, 5-dicarbonitrile (70, LUF 5853) shows full agonistic behavior comparable with the reference compound CPA, while also displaying comparable receptor binding affinity (Ki = 11 nM). In contrast, compound 58 (2-amino-4-(3- trifluoromethylphenyl)-6-(2-hydroxyethylsulfanyl)pyridine-3,5-dicarbonitrile, LUF 5948) has a binding affinity of 14 nM and acts as an inverse agonist. Also present within this same series are compounds that show neutral antagonism of the adenosine A1 receptor, for example compound 65 (2-amino-4-(4-difluoromethoxyphenyl)-6-(2-hydroxyethylsulfanyl)pyridine-3, 5-dicarbonitrile, LUF 5826).