791630-47-2Relevant academic research and scientific papers
Synthesis and characterization of new transplatinum complexes containing phosphane groups - Cytotoxic studies in cisplatin-resistant cells
Ramos-Lima, Francisco J.,Quiroga, Adoracion G.,Perez, Jose M.,Font-Bardia, Merce,Solans, Xavier,Navarro-Ranninger, Carmen
, p. 1591 - 1598 (2003)
In this paper we report the synthesis and characterization of novel trans platinum(ii) complexes of general formula trans[PtCl2(L)(PPh3)], where L is NH2CH(CH3)CH2CH3 (complex 1), (R)-NH2CH(CH3)CH2CH3 (complex 2), (S)-NH2CH(CH3)CH2CH3 (complex 3) and NH2CH(CH3)2 (complex 4). The new complexes contain phosphane ligands trans to the amine group. X-ray crystal structure determinations of complexes 1 and 3 confirmed their trans configurations. The cytotoxic activity of these complexes have been evaluated and compared with the activity of trans platinum complexes already viewed as potential drugs. ( Wiley-VCH Verlag GmbH & Co, KGaA, 69451 Weinheim, Germany, 2003).
