Synthesis and characterization of new transplatinum complexes containing phosphane groups - Cytotoxic studies in cisplatin-resistant cells

Article abstract of DOI:10.1002/ejic.200390209

In this paper we report the synthesis and characterization of novel trans platinum(ii) complexes of general formula trans[PtCl₂(L)(PPh₃)], where L is NH₂CH(CH₃)CH₂CH₃ (complex 1), (R)-NH₂CH(CH₃)CH₂CH₃ (complex 2), (S)-NH₂CH(CH₃)CH₂CH₃ (complex 3) and NH₂CH(CH₃)₂ (complex 4). The new complexes contain phosphane ligands trans to the amine group. X-ray crystal structure determinations of complexes 1 and 3 confirmed their trans configurations. The cytotoxic activity of these complexes have been evaluated and compared with the activity of trans platinum complexes already viewed as potential drugs. ( Wiley-VCH Verlag GmbH & Co, KGaA, 69451 Weinheim, Germany, 2003).