791775-31-0 Usage
Uses
Used in Pharmaceutical Research:
(1r,4r)-4-aminocyclohexane-1-carboxamide is used as a building block for the synthesis of various drugs, particularly those targeting the central nervous system.
Used as a Chiral Building Block:
(1r,4r)-4-aminocyclohexane-1-carboxamide is used as a chiral building block in the preparation of biologically active compounds and in the development of new pharmaceuticals.
Used in the Treatment of Neurological Disorders:
(1r,4r)-4-aminocyclohexane-1-carboxamide has potential applications in the treatment of neurological disorders.
Used in the Synthesis of Novel Chemical Entities:
(1r,4r)-4-aminocyclohexane-1-carboxamide is also used in the synthesis of novel chemical entities.
Check Digit Verification of cas no
The CAS Registry Mumber 791775-31-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,1,7,7 and 5 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 791775-31:
(8*7)+(7*9)+(6*1)+(5*7)+(4*7)+(3*5)+(2*3)+(1*1)=210
210 % 10 = 0
So 791775-31-0 is a valid CAS Registry Number.
791775-31-0Relevant academic research and scientific papers
Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2- ones as potent and selective mTOR kinase inhibitors
Mortensen, Deborah S.,Perrin-Ninkovic, Sophie M.,Harris, Roy,Lee, Branden G.S.,Shevlin, Graziella,Hickman, Matt,Khambatta, Gody,Bisonette, Rene R.,Fultz, Kimberly E.,Sankar, Sabita
, p. 6793 - 6799 (2012/01/03)
We report here the discovery of a novel series of selective mTOR kinase inhibitors. A series of imidazo[4,5-b]pyrazin-2-ones, represented by screening hit 1, was developed into lead compounds with excellent mTOR potency and exquisite kinase selectivity. Potent compounds from this series show >1000-fold selectivity over the related PI3Kα lipid kinase. Further, compounds such as 2 achieve mTOR pathway inhibition, blocking both mTORC1 and mTORC2 signaling, in PC3 cancer cells as measured by inhibition of pS6 and pAkt (S473).
