791796-92-4Relevant academic research and scientific papers
Photoredox-Mediated Remote C(sp3)-H Heteroarylation of N-Alkyl Sulfonamides
Deng, Zhiqiang,Li, Guo-Xing,He, Gang,Chen, Gong
, p. 15777 - 15787 (2019)
A Minisci-type δ-selective C(sp3)-H heteroarylation of sulfonyl-protected primary aliphatic amines with N-heteroarenes under photoredox-catalyzed conditions was developed. The reaction typically uses a slight excess of amine reactant. The use of benziodoxole acetate (BI-OAc) oxidant and hexafluoroisopropanol solvent is critical to achieve high yield. Besides methylene C-H bonds, heteroarylation reactions of δmethyl C-H bonds also worked under more forced conditions. The reactions show a broad scope for both amine and N-heteroarene substrates, offering a straightforward method for synthesis of complex δ-heteroarylalkylmines from simple precursors.
