791809-67-1

Upstream product

• 75-61-6 dibromodifluoromethane 
• 791809-54-6 3,4-epoxy-6-phenyl-4-(2-phenylethyl)hexan-2-one 
• 104-53-0 3-phenyl-propionaldehyde 
• 3277-89-2 phenethylmagnesium bromide 
• 17486-86-1 1,5-diphenylpentan-3-ol 
• 5396-91-8 1,5-diphenyl-3-pentanone 
• 791809-40-0 6-phenyl-4-(2-phenylethyl)hex-3-en-2-one 
• 791809-38-6 4-hydroxy-6-phenyl-4-(2-phenylethyl)hexan-2-one 

Relevant academic research and scientific papers

Preparation and regioselective SN2′ reaction of novel gem-difluorinated vinyloxiranes with RLi

A series of hitherto unknown 3,4-epoxy-1,1-difluorobutenes were prepared from the readily accessible α,β-epoxy ketones and these compounds were found to undergo regioselective SN2′ reactions with hard RLi nucleophiles occurring at the highly positively charged terminal fluorine-possessing sp2 carbon atom in quite sharp contrast to the cases of the corresponding nonfluorinated vinyloxiranes which only attained a low level of regioselectivity. Addition of HMPA substantially improved the products' olefinic stereoselectivity. Theoretical calculations were used to qualitatively explore the nature of selectivity in these reactions.