17486-86-1

Upstream product

• 67-56-1 methanol 
• 538-58-9 1,5-diphenyl-1,4-pentadiene-3-one 
• 67-64-1 acetone 
• 100-51-6 benzyl alcohol 
• 935662-20-7 (S,S^S)-1-chloro-3-phenylpropyl p-tolyl sulfoxide 
• 165904-22-3 4,4,5,5-tetramethyl-2-phenethyl-1,3,2-dioxaborolane 
• 5396-91-8 1,5-diphenyl-3-pentanone 
• 58681-16-6 7,7-bis-(phenylthio)bicyclo<4.1.0>heptane 
• 100-42-5 styrene 
• 122-97-4 3-Phenyl-1-propanol 
• 2344-70-9 1-phenyl-3-butanol 
• 100-52-7 benzaldehyde 
• 35225-79-7 dibenzylideneacetone 
• 104-53-0 3-phenyl-propionaldehyde 

Downstream Products

• 40939-59-1 pent-2-ene-1,5-diyldibenzene 
• 89113-44-0 1,5-diphenyl-3-bromopentane 
• 5396-91-8 1,5-diphenyl-3-pentanone 
• 29766-50-5 N-(1-phenethyl-3-phenyl-propyl)amine 
• 17486-89-4 p-Toluolsulfonsaeure-(1,5-diphenyl-pentyl-3-ester) 
• 1333156-03-8 1,5-diphenylpentan-3-yl acrylate 
• 54833-31-7 1,5-dicyclohexylpentane 
• 1718-50-9 1,5-diphenylpentane 
• 791809-67-1 3,4-epoxy-1,1-difluoro-2-methyl-6-phenyl-4-(2-phenylethyl)hex-1-ene 
• 791809-38-6 4-hydroxy-6-phenyl-4-(2-phenylethyl)hexan-2-one 

Relevant academic research and scientific papers

Titanocene(II)-promoted carbonyl cyclopropylidenation utilizing 1,1-dichlorocyclopropanes

A variety of alkylidenecyclopropanes bearing various substituents on their cyclopropane ring were obtained by the titanocene(II)-promoted reaction of 1,1-dichlorocyclopropane derivatives with carbonyl compounds including esters and lactones.

Modulating the rotation of a molecular rotor through hydrogen-bonding interactions between the rotator and stator

Two molecular rotors were synthesized (see picture). An investigation of the rotator rotation based on the imaginary parts of the complex dielectric constant (ε′′) for each molecular rotor at various frequencies and temperatures revealed that the rotation

COMPOUND AND LUBRICANT COMPOSITION

PROBLEM TO BE SOLVED: To provide a novel compound and a lubricant composition. SOLUTION: There is provided a compound which has a carbon number in the range of 25 or more and 45 or less, contains carbon and hydrogen and may contain oxygen, contains one or more unsaturated bonds, has a chain hydrocarbon group constituting the main chain, has 1 or more and 5 or less branched groups, has a cyclic hydrocarbon group at at least one terminal of the main chain and has 1 or more and 2 or less cyclic hydrocarbon groups as the branched group. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Antimicrobial Activity of Monoketone Curcuminoids Against Cariogenic Bacteria

We evaluated the antimicrobial activity of 25 monoketone curcuminoids (MKCs) against a representative panel of cariogenic bacteria in terms of their minimum inhibitory concentration (MIC) values. Curcumin A (10) displayed promising activity against Streptococcus mutans (MIC?=?50?μg/ml) and Streptococcus mitis (MIC?=?50?μg/ml) as well as moderate activity against S.?sanguinis (MIC?=?100?μg/ml), Lactobacillus casei (MIC?=?100?μg/ml), and Streptococcus salivarius (MIC?=?200?μg/ml). Results indicated higher activity of compound 10 than that of its bis-β-diketone analog. Additionally, compounds 3a (1,5-bis(4-methylphenyl)pentan-3-one) and 7b (1,5-bis(4-bromophenyl)pentan-3-ol) were moderately active against S.?mitis (MIC?=?100?μg/ml) and S.?salivarus (MIC?=?200?μg/ml).

Hydrogenation of Ketones and Esters Catalyzed by Pd/C?SiO2

Hydrogenation of unsaturated ketones and esters with molecular hydrogen on the 5%Pd/C?SiO2 heterogeneous catalyst has been studied. The reaction direction and yield are determined by the starting compounds structure. Hydrogenation of unsaturated ketones containing phenyl group at the double carbon–carbon atom is accompanied by the reduction of the ketone group into the alcohol one. Hydrogenation of unsaturated esters is accompanied by transesterification.

Investigation of the Deprotonative Generation and Borylation of Diamine-Ligated α-Lithiated Carbamates and Benzoates by in Situ IR spectroscopy

Diamine-mediated α-deprotonation of O-alkyl carbamates or benzoates with alkyllithium reagents, trapping of the carbanion with organoboron compounds, and 1,2-metalate rearrangement of the resulting boronate complex are the primary steps by which organoboron compounds can be stereoselectively homologated. Although the final step can be easily monitored by 11B NMR spectroscopy, the first two steps, which are typically carried out at cryogenic temperatures, are less well understood owing to the requirement for specialized analytical techniques. Investigation of these steps by in situ IR spectroscopy has provided invaluable data for optimizing the homologation reactions of organoboron compounds. Although the deprotonation of benzoates in noncoordinating solvents is faster than that in ethereal solvents, the deprotonation of carbamates shows the opposite trend, a difference that has its origin in the propensity of carbamates to form inactive parasitic complexes with the diamine-ligated alkyllithium reagent. Borylation of bulky diamine-ligated lithiated species in toluene is extremely slow, owing to the requirement for initial complexation of the oxygen atoms of the diol ligand on boron with the lithium ion prior to boron-lithium exchange. However, ethereal solvent, or very small amounts of THF, facilitate precomplexation through initial displacement of the bulky diamines coordinated to the lithium ion. Comparison of the carbonyl stretching frequencies of boronates derived from pinacol boronic esters with those derived from trialkylboranes suggests that the displaced lithium ion is residing on the pinacol oxygen atoms and the benzoate/carbamate carbonyl group, respectively, explaining, at least in part, the faster 1,2-metalate rearrangements of boronates derived from the trialkylboranes.

Manganese-Catalyzed β-Alkylation of Secondary Alcohols with Primary Alcohols under Phosphine-Free Conditions

Manganese(I) complexes bearing a pyridyl-supported pyrazolyl-imidazolyl ligand efficiently catalyzed the direct β-alkylation of secondary alcohols with primary alcohols under phosphine-free conditions. The β-alkylated secondary alcohols were obtained in moderate to good yields with water formed as the byproduct through a borrowing hydrogen pathway. β-Alkylation of cholesterols was also effectively achieved. The present protocol provides a concise atom-economical method for C-C bond formation from primary and secondary alcohols.

Tandem Cross Coupling Reaction of Alcohols for Sustainable Synthesis of β-Alkylated Secondary Alcohols and Flavan Derivatives

A Ru(II) NHC complex (loading down to 0.001 mol%) catalyzed cross coupling of a broad range of aromatic, aliphatic and heterocyclic alcohols is reported. This protocol also functioned efficiently under solvent-free conditions. Remarkably, this catalytic system disclosed so far the highest TON of 288000 for the cross coupling of alcohols. Notably, this methodology was successfully applied for the one-pot synthesis of a range of flavan derivatives. A detailed DFT studies and kinetic experiments were performed to understand the reaction mechanism as well as the high reactivity of this catalytic system. (Figure presented.).

Regioselective Hydrohydroxyalkylation of Styrene with Primary Alcohols or Aldehydes via Ruthenium-Catalyzed C?C Bond Forming Transfer Hydrogenation

Transfer hydrogenative coupling of styrene with primary alcohols using the precatalyst HClRu(CO)(PCy3)2modified by AgOTf or HBF4delivers branched or linear adducts from benzylic or aliphatic alcohols, respectively. Related

Ruthenium(III)-Catalyzed β-Alkylation of Secondary Alcohols with Primary Alcohols

A Ru(III)-NNN complex bearing a pyridyl-supported pyrazolyl-imidazolyl ligand was synthesized and utilized as the catalyst for the direct β-alkylation of secondary alcohols with primary alcohols. β-Alkylated secondary alcohols were obtained in moderate to high yields with water formed as the byproduct through a hydrogen borrowing pathway. The present protocol provides a concise atom-economical and environmentally benign method for C-C bond formation.