791834-68-9Relevant academic research and scientific papers
AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES
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, (2015/12/18)
The present invention provides a compound of Formula (I) or Formula (II): enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula (I) and (II) are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis
Yao, Wenqing,Zhuo, Jincong,Burns, David M.,Li, Yun-Long,Qian, Ding-Quan,Zhang, Colin,He, Chunhong,Xu, Meizhong,Shi, Eric,Li, Yanlong,Marando, Cindy A.,Covington, Maryanne B.,Yang, Gengjie,Liu, Xiangdong,Pan, Max,Fridman, Jordan S.,Scherle, Peggy,Wasserman, Zelda R.,Hollis, Gregory,Vaddi, Kris,Yeleswaram, Swamy,Newton, Robert,Friedman, Steve,Metcalf, Brian
, p. 159 - 163 (2008/09/19)
In an effort to obtain a MMP selective and potent inhibitor of HER-2 sheddase (ADAM-10), the P1′ group of a novel class of (6S,7S)-7-[(hydroxyamino)carbonyl]-6-carboxamide-5-azaspiro[2.5]octane-5-carboxylates was attenuated and the structure-activity rela
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer
Yao, Wenqing,Zhuo, Jincong,Burns, David M.,Xu, Meizhong,Zhang, Colin,Li, Yun-Long,Qian, Ding-Quan,He, Chunhong,Weng, Lingkai,Shi, Eric,Lin, Qiyan,Agrios, Costas,Burn, Timothy C.,Caulder, Eian,Covington, Maryanne B.,Fridman, Jordan S.,Friedman, Steven,Katiyar, Kamna,Hollis, Gregory,Li, Yanlong,Liu, Changnian,Liu, Xiangdong,Marando, Cindy A.,Newton, Robert,Pan, Max,Scherle, Peggy,Taylor, Nancy,Vaddi, Kris,Wasserman, Zelda R.,Wynn, Richard,Yeleswaram, Swamy,Jalluri, Ravi,Bower, Michael,Zhou, Bing-Bing,Metcalf, Brian
, p. 603 - 606 (2007/10/03)
The design, synthesis, evaluation, and identification of a novel class of (6S,7S)-N-hydroxy-6-carboxamide-5-azaspiro[2.5]octane-7-carboxamides as the first potent and selective inhibitors of human epidermal growth factor receptor-2 (HER-2) sheddase is des
