791836-59-4Relevant academic research and scientific papers
Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase
Gurulingappa, Hallur,Buckhalts, Phillip,Kinzler, Kenneth W.,Vogelstein, Bert,Khan, Saeed R.
, p. 3531 - 3533 (2007/10/03)
Renal dipeptidase (RDP) is an enzyme overexpressed in benign and malignant colorectal tumors. In an effort to identify potent inhibitors of this enzyme, a series of aminophosphinic acid derivatives were synthesized. Compounds 3a and 3c in which the phenyl
