791839-59-3

Usage

Chemical compound

4-(2,6-Dimethoxyphenyl)benzaldehyde

Structure

Benzaldehyde derivative with two methoxy groups located at the 2 and 6 positions of the phenyl ring

Uses

Building block in organic synthesis and pharmaceutical research

Properties

Valuable intermediate in the synthesis of pharmaceuticals and organic compounds
Unique structural and chemical properties
Potential applications in the development of new drugs and agrochemicals

Upstream product

• 2785-97-9 (2,6-dimethoxyphenyl)lithium 
• 192436-83-2 4-bromo-N-methoxy-N-methylbenzamide 

Relevant academic research and scientific papers

Synthesis of Substituted Benzaldehydes via a Two-Step, One-Pot Reduction/Cross-Coupling Procedure

The synthesis of functionalized (benz)aldehydes, via a two-step, one-pot procedure, is presented. The method employs a stable aluminum hemiaminal as a tetrahedral intermediate, protecting a latent aldehyde, making it suitable for subsequent cross-coupling with (strong nucleophilic) organometallic reagents, leading to a variety of alkyl and aryl substituted benzaldehydes. This very fast methodology also facilitates the effective synthesis of a 11C radiolabeled aldehyde. Aluminum-ate complexes enable transmetalation of alkyl fragments onto palladium and subsequent cross-coupling.