791846-40-7

Usage

Uses

Used in Pharmaceutical Research:
1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE is used as a reagent in chemical reactions and derivatizations. Its bromo and cyano groups on the phenyl ring enable the formation of new chemical entities with potential applications in various fields.
Used in Drug Synthesis:
1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE is used as an intermediate in the synthesis of pharmaceutical compounds. Its BOC protecting group allows for selective reactions on the phenyl ring, facilitating the synthesis of complex drug molecules.
Used in Medicinal Chemistry:
1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE is used as a template for the design of new drugs. Its unique structure and reactivity provide opportunities for the development of novel therapeutic agents with improved pharmacological properties.
Used in Chemical Synthesis:
1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE is used as a starting material for the synthesis of various organic compounds. Its bromo and cyano groups on the phenyl ring can be further modified or functionalized to create new chemical entities with potential applications in different industries.

InChI:InChI=1/C16H20BrN3O2/c1-16(2,3)22-15(21)20-8-6-19(7-9-20)14-5-4-13(17)10-12(14)11-18/h4-5,10H,6-9H2,1-3H3

Upstream product

• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 1163248-80-3 2-(4-(4-bromo-2-cyanophenyl)piperazin-1-yl)-N,N-diethyl-2-phenylacetamide 
• 791846-35-0 2-[4-(4-bromo-2-cyano-phenyl)-piperazin-1-yl]-N-(2,4,6-tribromo-3-methyl-phenyl)-acetamide 
• 791846-34-9 2-[4-(4-bromo-2-cyano-phenyl)-piperazin-1-yl]-N-(4-bromo-3-methyl-phenyl)-acetamide 
• 791846-41-8 5-bromo-2-piperazin-1-yl-benzonitrile 

Relevant academic research and scientific papers

Thiazolidine derivatives or salts thereof as an active ingredient an inhibitor Pim

PROBLEM TO BE SOLVED: To provide compounds which have excellent Pim inhibitory action and are useful as pharmaceuticals.SOLUTION: A compound is a thiazolidine derivative represented by the general formula (1) in the figure, or a salt thereof. (In the formula, X represents O or S; Rrepresents a hydrogen atom or a Calkyl group; Z, Z, Z, Z, Zand Zeach independently represent CH or N; Y represents an optionally substituted, divalent Caromatic hydrocarbon group or the like; Am represents a disubstituted amino group, or an optionally substituted, nitrogen-containing saturated heterocyclic group; and Rand Reach independently represent a hydrogen atom, a halogen atom, an alkyl group or the like.)

HETEROCYCLIC COMPOUNDS

The present invention provides a heterocyclic compound a TLR7 and/or TLR9 and/or TLR-7/8/9 and/or TLR-7/8 and/or TLR-7/9 inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases and/or inflammatory diseases and the like, in particular, acute decompensated heart failure, non-alcoholic steatohepatitis (NASH), IgA nephropathy, Duchenne muscular dystrophy (DMD), systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, psoriasis, inflammatory bowel disease, asthma, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, B-cell malignancies, transplant rejection and graft-versus-host disease, hepatocellular carcinoma (HCC) and the like. The present invention is a compound represented by the formula (1) : wherein each symbol is as described in the specification, or a salt thereof.

SYK INHIBITORS

The present disclosure a Syk compound inhibitors, including state cancer and inflammation and various disease States thereof in the treatment of relates to the use of. In one aspect a particular embodiment, . given by formula I which is marked as a chemical structure of compound. In formula said, X 1, X 2, X 3, R 2, R 3, R 4, R 5, and Y has described herein is. The present disclosure of a formula I compounds or a pharmaceutically acceptable salt of pharmaceutical compositions including, mediated by Syk and to treat conditions a employing these compounds and compositions further provides a method. (by machine translation)

BMP INHIBITORS AND METHODS OF USE THEREOF

The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR

The present invention is directed to piperidinyl and piperazinyl derivatives of formula (I) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of

Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl) piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: A selective dopamine D4 receptor agonist and radioligand

The first selective dopamine D4 agonist radioligand is described. The synthesis of these piperazine radioligands relied on the transformation of brominated precursors 4a and 4b with tritium gas in the presence of a sensitive cyano functional gr