79185-39-0Relevant academic research and scientific papers
Enantioselective iridium-catalyzed allylic arylation
Polet, Damien,Rathgeb, Xavier,Falciola, Caroline A.,Langlois, Jean-Baptiste,El Hajjaji, Samir,Alexakis, Alexandre
supporting information; experimental part, p. 1205 - 1216 (2009/09/06)
We describe herein the development of the first iridium-catalyzed allylic substitution using arylzinc nucleophiles. High enantioselectivities were obtained from the reactions, which used commercially available Grignard reagents as the starting materials. This methodology was also shown to be compatible with halogen/metal exchange reactions. Its synthetic potential is demonstrated by its application towards the formal synthesis of (+)-sertraline.
