79175-35-2

Usage

Uses

Used in Organic Synthesis:
3,4-Dichlorophenylmagnesium bromide is used as a reagent for the introduction of the 3,4-dichlorophenyl group in organic synthesis, allowing for the creation of new carbon-carbon bonds and the formation of a wide range of organic compounds.
Used in Pharmaceutical Preparation:
In the pharmaceutical industry, 3,4-Dichlorophenylmagnesium bromide is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs with specific therapeutic properties.
Used in Agrochemical Production:
3,4-Dichlorophenylmagnesium bromide is utilized in the agrochemical sector for the synthesis of compounds with pesticidal or herbicidal activity, enhancing crop protection and yield.
Used in Grignard Reactions:
3,4-Dichlorophenylmagnesium bromide is used as a nucleophilic agent in Grignard reactions, where it adds the 3,4-dichlorophenyl group to organic molecules, facilitating the formation of new carbon-carbon bonds and expanding the scope of organic chemistry.
Used in Research and Development:
In research settings, 3,4-Dichlorophenylmagnesium bromide is employed for exploring new reaction pathways and developing innovative synthetic methods, furthering the understanding of organic chemistry and its applications.

InChI:InChI=1/C6H3Cl2.BrH.Mg/c7-5-3-1-2-4-6(5)8;;/h1,3-4H;1H;/q-1;;+2/p-1

Upstream product

• 18282-59-2 4-bromo-1,2-dichlorobenzene 
• 7439-95-4 magnesium 

Downstream Products

• 100199-22-2 (1S,2S)-1-(3,4-Dichloro-phenyl)-2-imidazol-1-yl-cyclohexanol 
• 100199-22-2 (1S,2R)-1-(3,4-Dichloro-phenyl)-2-imidazol-1-yl-cyclohexanol 
• 100199-37-9 (1S,2S)-1-(3,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-yl-cycloheptanol 
• 144451-69-4 3-(3-Chloro-phenyl)-2-cyano-3-(3,4-dichloro-phenyl)-propionic acid methyl ester 
• 21270-03-1 4-[2-Bromo-1-(2-ethyl-hexyloxy)-ethyl]-1,2-dichloro-benzene 
• 851337-42-3 2-(3,4-dichloro-phenyl)-cyclohexanol 
• 146725-34-0 O-456 
• 196295-98-4 (1R,2S,3S,5S)-3-(3,4-Dichloro-phenyl)-8-prop-2-ynyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 
• 144451-82-1 3-(3-chlorophenyl)-3-(3,4-dichlorophenyl)-2-carbamoylpropanoic acid 
• 144290-59-5 N-Benzoyl-N'-[3-(3-chloro-phenyl)-3-(3,4-dichloro-phenyl)-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine 
• 144478-10-4 N-[3-(3-Chloro-phenyl)-3-(3,4-dichloro-phenyl)-propyl]-N'-[3-(1H-imidazol-4-yl)-propyl]-guanidine; hydrochloride 
• 144452-13-1 3-(3,4-dichlorophenyl)-3-(3-chlorophenyl)-propanamine 
• 4408-95-1 C₁₂H₉Cl₂N 
• 231953-61-0 3-(3,4-Dichlorophenyl)-1-(diphenylmethyl)azetidin-3-ol 

Relevant academic research and scientific papers

SELECTIVE INHIBITOR OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5)

The disclosure is directed to crystalline forms of the compound of Formula I, pharmaceutically acceptable salts of the compound of Formula I, and crystalline forms thereof. Pharmaceutical compositions comprising said crystalline forms and salts, as well a

A method for preparing substituted biphenyl

The invention discloses a preparation method of substituted biphenyl. The preparation method includes the steps that under the anhydrous condition, a compound 2 and a compound 3 are subjected to a coupled reaction in solvent in the presence of Ni salt and ZnX3X4, and then substituted biphenyl is obtained, wherein Ni salt is one or more of NiX5X6(PPh3)2, NiX7X8(dppp), NiX9X10(dppf), NiX11X12(dppe) and acetylacetone nickel, the temperature of the coupled reaction is 0-30 DEG C, and ZnX3X4 is mixed with the compound 3 before the compound 2 is mixed with the compound 3. According to the method, reaction conditions are mild, the process is simple, operation is safe, requirements for equipment are low, aftertreatment is simple, pollution to the environment is small, industrial production is easy, the usage quantity of zinc halides is small, the cost is low, the yield is high, and the product purity is high.

(3,4-DICHLORO-PHENYL)-((S)-3-PROPYL-PYRROLIDIN-3-YL)-METHANONE HYDROCHLORIDE AND MANUFACTURING PROCESSES

The present invention is concerned with a novel process for the preparation of a compound of formula I and its hydrates, as well as with a crystall polymorph thereof. The compounds of formula (I) and the corresponding hydrates are pharmaceutically active substances.

Piperdine derivatives useful as CCR3 antagonists

The use of CCR3 antagonists of the formula I or a pharmaceutically acceptable salt thereof for the treatment of asthma is disclosed, as well as novel compounds of the formula II, pharmaceutical compositions comprising them, and their use in the treatment