792174-58-4Relevant academic research and scientific papers
Metal-organocatalytic tandem azide addition/oxyamination of aldehydes for the enantioselective synthesis of β-amino α-hydroxy esters
Shyam, Pranab K.,Jang, Hye-Young
supporting information, p. 1817 - 1822 (2014/04/03)
The tandem reaction of α,β-unsaturated aldehydes with trimethylsilyl azide and 2,2,6,6-tetramethylpiperidin-1-yloxy in the presence of chiral amines and iron complexes as the catalysts in a one-pot reaction enantioselectively afforded β-azido α-oxyaminated aldehydes. Further synthetic modification of the product afforded β-amino α-hydroxy esters in good yields with good diastereo- and enantioselectivities.
Asymmetric synthesis of anti -β-amino-α-hydroxy esters via dynamic kinetic resolution of β-amino-α-keto esters
Goodman, C. Guy,Do, Dung T.,Johnson, Jeffrey S.
, p. 2446 - 2449 (2013/06/27)
A method for the asymmetric synthesis of enantioenriched anti-α-hydroxy-β-amino acid derivatives by enantioconvergent reduction of the corresponding racemic α-keto esters is presented. The requisite α-keto esters are prepared via Mannich addition of ethyl
