79221-02-6

Upstream product

• 79220-92-1 1-(4-Methoxy-phenyl)-4-phenyl-1H-imidazole-2-thiol 
• 190076-45-0 1-(4-methoxyphenyl)-4-phenyl-2,5-dihydro-1H-imidazole 3-oxide 
• 294674-79-6 dimethyl 5-(4-methoxyphenyl)-3a-phenyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole-2,3-dicarboxylate 
• 88333-03-3 Benzyl isocyanide 
• 10349-38-9 p-methoxyphenylisonitrile 
• 70-11-1 α-bromoacetophenone 
• 104-94-9 4-methoxy-aniline 
• 5883-82-9 2-((4-methoxyphenyl)amino)-1-phenylethanone 
• 713078-35-4 ethyl 2,3a-diphenyl-5-(p-methoxyphenyl)-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole-3-carboxylate 
• 333-20-0 potassium thioacyanate 

Relevant academic research and scientific papers

Tandem insertion-cyclization reaction of isocyanides in the synthesis of 1,4-diaryl-1H-imidazoles: Presence of N-arylformimidate intermediate

A straightforward and high-yielding synthesis of 1,4-diaryl-1H-imidazoles is reported. 1,4-Diaryl-1H-imidazoles have been difficult to access in ambient conditions, but our method utilizes two different facets of isocyanide reactivity to achieve it. The r

Thermal rearrangements of tetrahydroimidazo[1,5-b]isoxazole-2,3-dicarboxylates. Synthesis of 3H-imidazol-1-ium ylides and their silver derivatives

Isoxazolines 2 from the cycloaddition of imidazoline 3-oxides 1 with DMAD undergo rearrangement to 3,4-dihydro-2H-imidazol-1-ium-1-(1,2-bis-methoxycarbonyl-2-oxo-ethanides) 3, which spontaneously undergo elimination to give 3H-imidazol-1-ium-1-(1,2-bis-me

Synthesis of 4-oxo-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole-3-carboxylic acid esters

3-Imidazoline 3-oxides react regioselectively with 3-phenylpropanoic acid alkyl esters to give the corresponding 2-phenyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole-3-carboxylic acid alkyl esters. This adducts convert to imidazole and the corresponding al

Synthesis of di- and cis-triaryl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazoles and their ring-opening reactions

The Δ3-imidazoline 3-oxides 1 undergo diastereoselective cycloaddition with dimethyl acetylenedicarboxylate 2 to give 3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazoles 3. Thermally and base induced ring-opening reactions of compounds 3 were demonstra

The first examples of di- and cis triaryl-3a,4,5,6- tetrahydroimidazo[1,5-b]isoxazoles and their ring-opening reactions

The Δ3-imidazoline 3-oxides 1 undergo diastereoselective cycloaddition with dimethyl acetylenedicarboxylate 2 to give 3a,4,5,6- tetrahydroimidazo[1,5-b]isoxazoles 3. Thermal and base induced ring-opening reactions of compounds 3 were demonstrat

Hypervalent iodine mediated syntheses of heterocycles: One-pot facile syntheses of 1,4-diaryl-2-mercaptoimidazoles, 2-(α-anilinoacetyl)thiophenes and 1-aryl-2-mercapto-4-(2-thienyl)imidazoles from aryl/2-thienyl methyl ketones

Successive treatment of acetophenones (1a-e) or 2-acetylthiophene (4) with benzene, appropriate aniline and KSCN/AcOH leads to the formation of 1,4-diaryl-2-mercaptoimidazoles (3aa-3ea) or 1-aryl-2-mercapto-4-(2-thienyl)imidazoles (6a-f) respectively.This procedure also provides 2(α-anilinoacetyl)thiophenes (5a-f) in one pot from 4.