79228-38-9

Upstream product

• 79228-37-8 6-(2-N-acetylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene 
• 74-88-4 methyl iodide 
• 500-99-2 3,5-dimethoxyphenol 
• 21421-66-9 5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran 
• 1111-97-3 3-chloro-3-methylbut-1-yne 

Downstream Products

• 79228-40-3 6-(2-N-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene 
• 79235-51-1 1-methyl-4-(5,7-dimethoxy-2,2-dimethylchromenyl)-quinol-2-one 
• 7008-42-6 acronine 

Relevant academic research and scientific papers

RUTACEOUS CONSTITUENTS-13 A BIOMIMETIC SYNTHESIS OF ACRONYCINE

A biomimetic synthesis of the anti-tumor active alkaloid acronycine (7; R=R'=Me) has been obtained by cyclisation of 6-(2-methylaminobenzoyl)-5,7-dimethoxy-2,2-dimethylchromene (11; R=R'=Me); isoacronycine (20; R=R'=Me) was also produced.In an analogous manner the aminochromene (11; R=H, R'=Me) gave a mixture of des-N-methylacronycine (7; R=H, R'=Me) and des-N-methylisoacronycine (20; R=H, R'=Me).The aminochromenes were best synthesised by condensation of lithio-5,7-dimethoxy-2,2-dimethylchromene (22; R=Li) with N-methylisatoic anhydride (26) or with 2-methyl-3,1-benzoxazin-4-one (21).The relevance of this synthetic route to the biogenesis of acridone alkaloids is discussed.