79232-88-5Relevant academic research and scientific papers
Cp*IrIII-Catalyzed [3+2] Annulations of N-Aryl-2-aminopyrimidines with Sulfoxonium Ylides to Access 2-Alkyl Indoles Through C–H Bond Activation
Luo, Yi,Guo, Lingmei,Yu, Xinling,Ding, Haosheng,Wang, Huijing,Wu, Yong
supporting information, p. 3203 - 3207 (2019/06/08)
The iridium-catalyzed aromatic C–H alkylation followed by intramolecular annulation reactions between N-aryl-2-aminopyridines and sulfoxonium ylides for the synthesis of 2-alkyl indoles is described. This highly efficient and step-economical cyclization r
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells
Medda, Federico,Sells, Earlphia,Chang, Hui-Hua,Dietrich, Justin,Chappeta, Shashi,Smith, Breland,Gokhale, Vijay,Meuillet, Emmanuelle J.,Hulme, Christopher
, p. 528 - 531 (2013/02/25)
This Letter reports the synthesis and biological evaluation of a collection of aminophthalazines as a novel class of compounds capable of reducing production of PGE2 in HCA-7 human adenocarcinoma cells. A total of 28 analogs were synthesized, a
