79233-15-1

Usage

Uses

Used in Pharmaceutical Industry:
ANDROGRAPHOLIDE, DEOXYis used as a therapeutic agent for its anti-inflammatory, antiviral, and antioxidant properties. It is particularly beneficial in treating respiratory infections, diabetes, and cancer due to its potential to modulate the immune response and enhance the immune system.
Used in Immune System Modulation:
ANDROGRAPHOLIDE, DEOXYis used as an immune system booster to enhance the body's natural defense mechanisms against various health conditions. Its ability to modulate the immune response makes it a valuable compound in the development of treatments for autoimmune diseases and other immune-related disorders.
Used in Anticancer Research:
ANDROGRAPHOLIDE, DEOXYis used as a potential anticancer agent in scientific research. Its potential to inhibit the growth and progression of cancer cells, as well as its ability to synergize with conventional chemotherapeutic drugs, makes it a promising candidate for the development of novel cancer treatments.
Used in Drug Delivery Systems:
ANDROGRAPHOLIDE, DEOXYis used in the development of innovative drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. Various organic and metallic nanoparticles have been employed as carriers for ANDROGRAPHOLIDE, DEOXYdelivery, aiming to enhance its efficacy and overcome limitations associated with its use in traditional formulations.

InChI:InChI=1/C20H30O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h9,16-17,21-22H,4-8,10-12H2,1-3H3/t16-,17+,19-,20-/m0/s1

Upstream product

• 42895-61-4 3,19-diacetyl-14-deoxyandrographolide 
• 142037-79-4 andrographolide 
• 82209-72-1 14-deoxyandrographolide 19-glucoside 
• 4176-97-0 14-deoxyandrographolide 

Relevant academic research and scientific papers

Synthesis of andrographolide analogues and their neuroprotection and neurite outgrowth-promoting activities

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and remains incurable. Currently, neuronal injury and synapse loss have been considered to be main features in the pathophysiology of AD. Thus, modulation of neuronal survival and neurite outgrowth may represent an efficient strategy for the treatment of AD. Based on the isolates from the traditional medicine Andrographis paniculata, a series of andrographolide analogues were prepared and evaluated for the neuroprotection and neurotrophic activity. Two compounds (3 and 12) could effectively inhibit LPS-induced NO production and iNOS expression as well as proinflammatory cytokines TNF-α and IL-6. Moreover, pretreatment with 3 and 12 could protect neurons against microglia-mediated neurotoxicity. Further, H2O2 ? and 6-OHDA induced neurotoxicity in PC12 cells were also attenuated by the novel 12. Our next study indicated that compounds 1, 4 and 10 promoted NGF-induced neurite outgrowth in PC12 cells, with 10 the most potent. To clarify the underlying mechanisms of active compounds (3, 10 and 12), system pharmacology was employed. The results revealed that muscarinic acetylcholine receptors (mAChRs) may be the main targets of 12 against AD, while thyroid hormone signaling pathway was involved in the mechanisms of 10. These study point to the therapeutic potential of andrographolide analogues against AD.

On the Diterpenoids of Andrographis paniculata: X-Ray Crystallographic Analysis of Andrographolide and Structure Determination of New Minor Diterpenoids

The crystal structure of andrographolide (8) was determined and the absolute configuration at C-14, which was previously undecided, was established as R.Reexamination of the constituents of Andrographis paniculata NEES resulted in the isolation of three new diterpenoids of ent-labdane type, andrographanin, andropanoside, and 14-deoxy-12-methoxy-andrographolide, together with three known compounds, 14-deoxyandrographolide (4), neoandrographolide (5) and andrographolide (8).The structures of the new diterpenoids were determined to be 1, 2, and 3 on the basis of spectral and chemical evidence.Keywords - Andrographis paniculata; acanthaceae; andrographolide; X-ray analysis; andrograpanin; andropanoside, 14-deoxy-12-methoxy-andrographolide; ent-labdane diterpenoid; structure elucidation