79258-03-0Relevant academic research and scientific papers
A General and Practical Approach for the Synthesis of 1,2,4-Trioxanes Catalyzed by Silica-Ferric Chloride
Zhang, Mo,Han, Yi,Niu, Jia-Liang,Zhang, Zhan-Hui
, p. 3618 - 3625 (2017)
An efficient and practical method has been developed for the facile synthesis of 1,2,4-trioxanes by the condensation of β-hydroperoxy alcohols and carbonyl compounds in the presence of a catalytic amount of silica-supported ferric chloride (FeCl3/SiO2) at room temperature. The method has the benefits of operational simplicity, high yields and potential large-scale application. Moreover, the catalyst can be readily recovered by simple filtration and reused up to five times while almost maintaining its catalytic activity. (Figure presented.).
Synthesis and Reaction of 1,2,4-Trioxanes
Fujisaka, Tomohiro,Miura, Masahiro,Nojima, Masatomo,Kusabayashi, Shigekazu
, p. 1031 - 1039 (2007/10/02)
The peroxides (1a-e) and epoxides (2a-g) in methylene dichloride were treated with tungsten (VI) oxide and then with catalitic amounts of chlorosulphonic acid to give the corresponding 1,2,4-trioxanes (3a-r) in 10-63percent yield.The mode of decomposition of the 1,2,4-trioxanes was studied by treating a number with the following reagents: triethylamine, sodium ethoxide, lithium di-isopropylamide, Grignard and lithium reagents, lithium aluminium hydride, anthrylsodium, triphenylphosphine, and titanium tetrachloride.
Synthesis of 1,2,4-Trioxans
Miura, Masahiro,Nojima, Masatomo,Kusabayashi, Shigekazu
, p. 581 - 582 (2007/10/02)
The reaction of a mixture of α-hydroxydecyl hydroperoxide and epoxides in the presence of tungstic anhydride and catalytic amounts of chlorosulphonic acid gave the corresponding 1,2,4-trioxans in 7 - 63 percent yield.
