79259-41-9

Basic information

• Product Name: Boc-Leu-Phe-Met-NH₂
• CAS NO: 79259-41-9
• Molecular Weight: 508.682
• Mol File: 79259-41-9.mol

Chemical Properties

• CAS DataBase Reference: Boc-Leu-Phe-Met-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Leu-Phe-Met-NH₂(79259-41-9)
• EPA Substance Registry System: Boc-Leu-Phe-Met-NH₂(79259-41-9)

Safety Data

• Hazardous Substances Data: 79259-41-9(Hazardous Substances Data)

Upstream product

• 4510-08-1 L-methioninamide 
• 15136-32-0 (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester 

Relevant articles and documents

α-Chymotrypsin-catalyzed Synthesis of Tripeptide Amides in an Aqueous-Organic Two-phase System

α-Chymotrypsin catalyzes in a biphasic system containing an organic solvent and hydrogencarbonate buffer the reaction of Boc-Leu-Phe-OMe with X-NH2 (X=Leu, Met, Val) forming Boc-tripeptide amides.In the case of X=Leu the addition of ammoniumsulfate is advantageous and allows the use of carboxyl and amino component in equivalent amounts.By the same method Z-protected tripeptide amides can be prepared from Z-X-Phe-OMe (X=Ala, Leu, Val) and Leu-NH2 in good yields.In some case α-chymotrypsin-catalyzed peptide coupling is also possible, if the buffer solution is substituted for crystal water containing sodium carbonate.