15136-32-0

Basic information

• Product Name: D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-, methyl ester
• CAS NO: 15136-32-0
• Molecular Formula: C21H32N2O5
• Molecular Weight: 392.495
• Mol File: 15136-32-0.mol
• Article Data: 56

Chemical Properties

• CAS DataBase Reference: D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-, methyl ester(15136-32-0)
• EPA Substance Registry System: D-Phenylalanine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-, methyl ester(15136-32-0)

Safety Data

• Hazardous Substances Data: 15136-32-0(Hazardous Substances Data)

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 67436-23-1 phenylalanine methyl ester tosylate 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 17349-27-8 NPS-Phe-OMe 
• 2688-22-4 Nps-L-Phe-OH 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 200937-21-9 N-tert-butoxycarbonyl-L-leucine monohydrate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 61-90-5 L-leucine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 63-91-2 L-phenylalanine 
• 66866-44-2 Boc-Leu-O-COO-isoBu 
• 140834-91-9 (S)-benzyl 2-((S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido)-3-phenylpropanoate 
• 13033-84-6 D-phenylalanine methyl ester hydrochloride 

Downstream Products

• 145250-92-6 (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 
• 84077-69-0 Boc-Leu-Phe-OC₃H₇-i 
• 859-45-0 N-trifluoroacetyl-leucylphenylalanine methylester 
• 1285537-76-9 Boc-Thia-Leu-Phe-OMe 
• 1371597-18-0 C₂₇H₄₃N₃O₆ 
• 1365292-35-8 L-isoseryl-L-leucyl-L-phenylalanine methyl ester hydrochloride 
• 868539-96-2 (S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate 
• 1414357-46-2 methyl (S)-2-{(S)-2-[2-((S)-2-{4-[(8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6Hcyclopenta[a]phenanthren-17-yl]-1H-1,2,3-triazol-1-yl}propanamido)acetamido]-4-methylpentanamido}-3-phenylpropanoate 
• 1414357-91-7 methyl (S)-2-((S)-2-{2-[(S)-2-azidopropanamido]acetamido}-4-methylpentanamido)-3-phenylpropanoate 
• 108456-25-3 methyl (2S,5S)-2-benzyl-8-[(tert-butoxycarbonyl)amino]-5-isobutyl-4,7-dioxo-3,6-diazaoctanoate 
• 1374225-27-0 C₅₅H₉₃N₉O₁₂ 

Relevant articles and documents

Preparation and biological evaluation of soluble tetrapeptide epoxyketone proteasome inhibitors

A series of novel tetrapeptidyl epoxyketone inhibitors of 20S proteasome was designed and synthesized. To fully understand the SAR, various groups at R1, R2, R3, R4 and R5 positions, including aromatic and aliphatic substituents were designed, synthesized and biologically assayed. Based on the enzymatic results, seven compounds were selected to evaluate their cellular activities and soluble compound 36 showed strong potency against human multiple myeloma (MM) cell lines. Microsomal stability results indicated that compound 36 was more stable in mice, rat and human microsomes than marketed carfilzomib. The in vivo activities of this compound were evaluated with the xenograft mice models of MM cell lines ARH77 and RPMI-8226 with luciferase expression and the T/C value of the two models were 49.5% and 37.6%, respectively. To evaluate the potential cardiovascular toxicity, inhibition of hERG ion channel in HEK293 cells by compound 36 and carfilzomib was carried out. The results indicated that 36 had no binding affinity for the hERG ion channel while carfilzomib could bind it with IC50 of 92.1 μM.

Pd-Catalyzed Site-Selective C(sp2)-H Olefination and Alkynylation of Phenylalanine Residues in Peptides

Pd-catalyzed site-selective C(sp2)-H olefination and alkynylation of phenylalanine residues in peptides are described. The amino acids within the peptides are used as native bidentate directing groups to facilitate C-H functionalization. This p

Pd-catalyzed intramolecular C(sp2)-H amination of phenylalanine moieties in dipeptides: Synthesis of indoline-2-carboxylate-containing dipeptides

A palladium-catalyzed intramolecular C(sp2)-H amination of phenylalanine moieties in dipeptides is described. By this protocol, a series of indoline-2-carboxylate-containing dipeptides were synthesized from dipeptides. The N-protected amino aci