79276-58-7

Usage

Chemical structure

QP is a heterocyclic compound with a quinolinyl and pyrrolidinone functional group.

Building block

It is often used as a building block for various medicinal and pharmaceutical compounds.

Versatile reactivity

QP has versatile reactivity, making it suitable for use in the synthesis of different compounds.

Stability

The compound is known for its stability, which is an important factor in pharmaceutical applications.

Drug discovery and development

QP has been studied for its potential applications in drug discovery and development.

Asymmetric synthesis

It has been investigated as a ligand or catalyst in asymmetric synthesis, a key technique in the production of enantiomerically pure compounds.

Anticancer potential

QP has demonstrated potential as an anticancer agent in preclinical studies.

Anti-inflammatory potential

The compound has also shown promise as an anti-inflammatory agent in preclinical studies.

Pharmaceutical industry

QP is a promising candidate for further research and development in the pharmaceutical industry due to its various potential applications and properties.

InChI:InChI=1/C13H12N2O/c16-12-7-3-9-15(12)11-6-1-4-10-5-2-8-14-13(10)11/h1-2,4-6,8H,3,7,9H2

Upstream product

• 578-66-5 8-amino quinoline 
• 98-59-9 p-toluenesulfonyl chloride 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 23382-09-4 silicon dioxide hydrate 
• 14453-65-7 1-(2-aminophenyl)pyrrolidin-2-one 
• 7664-93-9 sulfuric acid 
• 107-02-8 acrolein 
• 56-37-1 N-benzyl-N,N,N-triethylammonium chloride 

Relevant academic research and scientific papers

Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity

(3-Pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines were prepared via cyclization of diallylaminoquinolines and 4-chloro-N-quinolinylbutanamides, respectively, as novel synthetic intermediates en route to N-functionalized 3-, 5-, 6- and 8-aminoquinolines with potential biological activity. (3-Pyrrolin-1-yl)quinolines were subjected to bromination reactions, and the reactivity of (2-oxopyrrolidin-1-yl)quinolines toward lithium aluminum hydride and methyllithium was assessed, providing an entry into a broad range of novel functionalized (pyrrolidin-1-yl)- and (hydroxyalkylamino)quinolines. Antiplasmodial evaluation of these novel quinolines and their functionalized derivatives revealed moderate micromolar potency against a chloroquine-sensitive strain of the malaria parasite Plasmodium falciparum, and the two most potent compounds also showed micromolar activity against a chloroquine-resistant strain of P. falciparum. Antifungal assessment of (hydroxyalkylamino)quinolines revealed three compounds with promising MIC values against Rhodotorula bogoriensis and one compound with potent activity against Aspergillus flavus.

1-(8-Quinolyl)-2-pyrrolidone and its pharmaceutical compositions

The compound of formula (I) STR1 and acid addition salts thereof are of value in medicine in the treatment or prophylaxis of pain, inflammation or fever. The compound and its salts may be administered alone or as a pharmaceutical formulation. The compound may be prepared by methods analogous to those known in the art or, for example, by cyclization of a 4-halo-N-(8-quinolyl)butyramide in the presence of aqueous sodium hydroxide and a phase transfer catalyst such as triethylbenzyl ammonium chloride.