79279-28-0Relevant articles and documents
Synthesis method of vitamin A higher fatty acid ester
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Paragraph 0052; 0053, (2016/11/09)
The invention discloses a synthesis method of vitamin A higher fatty acid ester, which includes the following steps: a) performing an esterification reaction to vitamin A alcohol and higher fatty acid anhydride in an organic solvent under catalysis of an alkaline metal oxide; and b) performing after treatment after the reaction is finished to obtain the vitamin A higher fatty acid ester. The method is less in reaction by-products, is high in product purity and is good in product quality. The product is more than 97.5% in content and is more than 96.5% in yield through high performance liquid chromatography detection. The vitamin A higher fatty acid ester enables storage, transportation and application of vitamin A to be more convenient. An analytic method in pharmacopeia proves that vitamin A palmitate is 1750000-1780000 IU/g in biological titer and is more than 97.5% in content through the high performance liquid chromatography detection, so that the vitamin A palmitate can be marketed as commodity directly, and is widely applied in the fields of medicines, feed additives and food additives.