79289-52-4Relevant academic research and scientific papers
PROCESSES FOR PREPARATION OF (S)-TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE
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Paragraph 00365, (2019/03/12)
Provided are processes for the preparation of (S)-tert-butyl 4,5-diamino-5-oxopentanoate, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof. Also provided are solid forms of various intermediates and products obtained from the processes.
A rapid and highly enantioselective C-11C bond formation of l-[11C]phenylalanine via chiral phase-transfer catalysis
Peko?ak, Aleksandra,Filp, Ulrike,?krinjar, Janja,Poot, Alex J.,Windhorst, Albert D.
supporting information, p. 570 - 575 (2017/01/25)
A rapid method for the synthesis of carbon-11 radiolabeled phenylalanine was developed using a chiral phase-transfer catalyst and a sub-nanomolar quantity of [11C]benzyl iodide as a radio-precursor. Based on a reported synthesis of [11/su
The regioselective α-alkylation of the benzophenone imine of glycinamide, alaninamide, and related derivatives
O'Donnell, Martin J.,Keeton, Jeremy D.,Van Khau, Vien,Bollinger, John C.
, p. 1301 - 1312 (2007/10/03)
The benzophenone imine of glycinamide was alkylated using ion pair extraction (RX, 10% aq. NaOH, Bu4NHSO4 (1 equiv.), CH 2Cl2, rt) to give the α-monosubstituted products, which were then alkylated a second time
PROCESS FOR THE PREPARATION OF AN α-AMINO CARBONYL COMPOUND
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Page 16-17, (2008/06/13)
The invention relates to a process for the preparation of an α-amino carbonyl compound by reacting an imine starting material with a suitable electrophile in the presence of a base. This process has the advantage that the imine starting materials can be prepared from glyoxylic acid esters or glyoxylic acid ester derivatives and α-hydrogen containing primary amines, which are usually cheap and readily available. These imine starting materials can usually be prepared with a high yield and/or almost without the formation of any side products.
Synthesis and properties of 3-oxo-1,2-diazetidinium ylides
Taylor, Edward C.,Haley, Neil F.,Clemens, Robert J.
, p. 7743 - 7752 (2007/12/18)
Treatment of α-chloroacylhydrazones of diaryl and certain aralkyl and dialkyl ketones with sodium hydride in anhydrous tetrahydrofuran gives 1-(disubstituted methylene)-3-oxo-1,2-diazetidinium inner salts (ylides). The reaction pathway involves formation of the hydrazone anion followed by intramolecular SN2 halide displacement (with complete inversion at the α carbon) by the sp2 imine nitrogen. These 1-(disubstituted methylene)-3-oxo-1,2-diazetidinium ylides are reduced by sodium borohydride to give 1-substituted 1,2-diazetidin-3-ones, undergo dipolar cycloaddition reactions to give fused aza-β-lactams, and can be hydrolyzed with p-toluenesulfonic acid monohydrate to the p-toluenesulfonic acid salt of 1,2-diazetidinone.
