792921-75-6Relevant academic research and scientific papers
Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin
Paterson, Ian,Britton, Robert,Delgado, Oscar,Gardner, Nicola M.,Meyer, Arndt,Naylor, Guy J.,Poullennec, Karine G.
experimental part, p. 6534 - 6545 (2010/10/03)
An efficient convergent synthesis of the anticancer marine macrolide (-)-dictyostatin is described that proceeds in 4.6% yield over 27 steps. Most of the stereocentres were configured using substrate control, making use of a common building block to insta
Synthesis of the C11-C23 fragment of the potent antitumor agent dlctyostatin
Dias, Luiz C.,Lima, Dimas J.P.,Goncalves, Caroline C.S.,Andricopulo, Adriano D.
supporting information; experimental part, p. 1491 - 1494 (2009/07/11)
We wish to report here our initial efforts toward the total synthesis of the potent antitumor agent dlctyostatin, describing a short and efficient synthesis of the C11-C23 fragment. Wiley-VCH Verlag GmbH & Co. KGaA.
Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers
Shin, Youseung,Fournier, Jean-Hugues,Brückner, Arndt,Madiraju, Charitha,Balachandran, Raghavan,Raccor, Brianne S.,Edler, Michael C.,Hamel, Ernest,Sikorski, Rachel?P.,Vogt, Andreas,Day, Billy W.,Curran, Dennis P.
, p. 8537 - 8562 (2008/02/09)
Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin, and a number of other isomers and analogs are reported. Three main fragments-top, middle, and bottom-were first assembled and then joined by olefination or anio
ANALOGS OF DICTYOSTATIN, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF
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, (2008/06/13)
Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and i
METHODS FOR THE SYNTHESIS OF DICTYOSTATIN AND DERIVATIVES AND ANALOGUES THEREOF, STEREOCHEMICAL CHARACTERISATION, NOVEL DICTYOSTATIN COMPOUNDS AND USES THEREOF AND SYNTHETIC INTERMEDIATES
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Page/Page column 47-48; 149-150, (2010/02/13)
A method for the synthesis of dictyostatin or a derivative thereof having Formula (I) is provided.
Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin
Paterson, Ian,Britton, Robert,Delgado, Oscar,Meyer, Arndt,Poullennec, Karine G.
, p. 4629 - 4633 (2007/10/03)
A flexible and modular approach was used in the convergent and highly stereocontrolled synthesis of the antimitotic agent dictyostatin. This first total synthesis establishes its full stereochemistry and should be amenable to producing useful quantities a
Total synthesis of (-)-dictyostatin: Confirmation of relative and absolute configurations
Shin, Youseung,Fournier, Jean-Hugues,Fukui, Yoshikazu,Brueckner, Arndt M.,Curran, Dennis P.
, p. 4634 - 4637 (2007/10/03)
Will the real dictyostatin please stand up? There were five finalists as stereostructures for the potent anticancer agent dictyostatin; ten, if one were to include enantiomers. A total synthesis of (-)-dictyostatin (1) has ended the decade-old masquerade
