132969-64-3

Basic information

• Product Name: tert-Butyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-dimethyl-silane
• Synonyms: tert-Butyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-dimethyl-silane
• CAS NO: 132969-64-3
• Molecular Weight: 492.513
• Mol File: 132969-64-3.mol

Chemical Properties

• CAS DataBase Reference: tert-Butyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-dimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-dimethyl-silane(132969-64-3)
• EPA Substance Registry System: tert-Butyl-[(1S,2S)-1-((R)-2-iodo-1-methyl-ethyl)-3-(4-methoxy-benzyloxy)-2-methyl-propoxy]-dimethyl-silane(132969-64-3)

Safety Data

• Hazardous Substances Data: 132969-64-3(Hazardous Substances Data)

Upstream product

• 792911-22-9 (-)-(2S,3R,4S)-3-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentan-1-ol 
• 496035-49-5 methyl (2R,3S,4S)-2,4-dimethyl-3-hydroxy-5-(4-methoxybenzyloxy)pentanoate 
• 133007-95-1 (2S,3R,4S)-5-[(4-methoxybenzyl)oxy]-2,4-dimethylpentane-1,3-diol 
• 792911-21-8 (2S,3S,4S)-1,3-bis[(tert-butyldimethylsilyl)oxy]-5-[(4-Methoxybenzyl)oxy]-2,4-dimethylpentane 
• 303727-83-5 (-)-(R)-4-benzyl-3-((2R,3S,4S)-3-hydroxy-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 443761-65-7 (-)-(R)-4-benzyl-3-((2R,3S,4S)-3-((tert-butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)-2,4-dimethylpentanoyl)oxazolidin-2-one 

Downstream Products

• 132969-66-5 (4S,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-1-[3-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-heptan-1-one 
• 792911-23-0 (2R,4S,5R,6S)-7-(4-methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,2,4,6-tetramethylheptanamide 
• 792911-19-4 (2R,4S,5R,6S)-7-(4-methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptanal 
• 792911-24-1 (3Z,9E)-(5S,6S,7R,11R,13S,14R,15S)-14-(tert-Butyl-dimethyl-silanyloxy)-6,16-bis-(4-methoxy-benzyloxy)-5,7,11,13,15-pentamethyl-hexadeca-1,3,9-trien-8-one 
• 132969-70-1 (2R,8S,9R,10S,13S)-9-(tert-Butyl-dimethyl-silanyloxy)-7-hydroxy-13-methoxy-1-(4-methoxy-benzyloxy)-2,4,4,8,10-pentamethyl-13-[3-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-tridecan-5-one 
• 132969-67-6 (1S,4S,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-4,6-dimethyl-1-[3-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-heptan-1-ol 
• 132969-59-6 (2R,3R,4S,7S)-3-(tert-Butyl-dimethyl-silanyloxy)-7-methoxy-2,4-dimethyl-7-[3-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-heptanal 
• 132969-68-7 (2S,3R,4S,7S)-3-(tert-Butyl-dimethyl-silanyloxy)-7-methoxy-2,4-dimethyl-7-[3-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-heptan-1-ol 
• 945401-95-6 (2S,4S,5R,6S)-7-(4-methoxybenzyloxy)-5-(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptan-1-ol 
• 945402-25-5 (4R,5S,7S,10S,11R,12S,14S,E)-5,11-bis(tert-butyldimethylsilyloxy)-4,10,12,14-tetramethyl-15-(triethylsilyloxy)-1-(trityloxy)pentadec-2-en-8-yn-7-ol 
• 945402-24-4 (4R,5S,10S,11R,12S,14S,E)-5,11-bis(tert-butyldimethylsilyloxy)-4,10,12,14-tetramethyl-15-(triethylsilyloxy)-1-(trityloxy)pentadec-2-en-8-yn-7-one 
• 960074-25-3 1-(((2S,3R,4S,6S)-3,7-bis(tert-butyldimethylsilyloxy)-2,4,6-trimethylheptyloxy)methyl)-4-methoxybenzene 
• 871236-59-8 (2S,4S,5S)-4-((2R,3S,6S,8S,9R,10S,11Z,13S,15S,16R,17E)-3,9,13,15-tetrakis(tert-butyldimethylsilyloxy)-6,8,10,16-tetramethyl-19-(trityloxy)nonadeca-11,17-dien-2-yl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxane 
• 792921-87-0 (2S,4S,5S)-4-((2R,3R,6S,8S,9R,10S,11Z,13S,15S,16R,17E)-3,9,13,15-tetrakis(tert-butyldimethylsilyloxy)-6,8,10,16-tetramethyl-19-(trityloxy)nonadeca-11,17-dien-2-yl)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxane 

Relevant articles and documents

Total synthesis of (-)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin

An efficient convergent synthesis of the anticancer marine macrolide (-)-dictyostatin is described that proceeds in 4.6% yield over 27 steps. Most of the stereocentres were configured using substrate control, making use of a common building block to insta

Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers

Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin, and a number of other isomers and analogs are reported. Three main fragments-top, middle, and bottom-were first assembled and then joined by olefination or anio

ANALOGS OF DICTYOSTATIN, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF

Dictyostatin and its analogs show great promise as new anticancer agents. The present invention provides dictyostatin analogs, synthetic intermediates for the synthesis of dictyostatin analogs, and synthetic methods for the synthesis of such analogs and i

METHODS FOR THE SYNTHESIS OF DICTYOSTATIN AND DERIVATIVES AND ANALOGUES THEREOF, STEREOCHEMICAL CHARACTERISATION, NOVEL DICTYOSTATIN COMPOUNDS AND USES THEREOF AND SYNTHETIC INTERMEDIATES

A method for the synthesis of dictyostatin or a derivative thereof having Formula (I) is provided.

Total synthesis and configurational assignment of (-)-dictyostatin, a microtubule-stabilizing macrolide of marine sponge origin

A flexible and modular approach was used in the convergent and highly stereocontrolled synthesis of the antimitotic agent dictyostatin. This first total synthesis establishes its full stereochemistry and should be amenable to producing useful quantities a

Total synthesis of (-)-dictyostatin: Confirmation of relative and absolute configurations

Will the real dictyostatin please stand up? There were five finalists as stereostructures for the potent anticancer agent dictyostatin; ten, if one were to include enantiomers. A total synthesis of (-)-dictyostatin (1) has ended the decade-old masquerade

Expeditious synthesis of a key C9-C21 subunit of the aplysiatoxins and oscillatoxins

The C9-C21 portion of the aplysiatoxin/oscillatoxin bluegreen algal metabolites was synthesized as the 9-aldehyde bearing a tert-butyldimethylsilyl ether group on the C11 hydroxyl and a trimethylsilylethoxymethyl ether gro