79297-22-6Relevant academic research and scientific papers
Process for preparing β-hydroxycarbamates and their conversion to oxazolidinones
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Example 3, (2008/06/13)
A process for preparing a β-hydroxy carbamate product is disclosed. The process comprises reacting an olefin compound containing at least one carbon-carbon double bond with a carbamate in an aqueous solvent and in the presence of a base, an osmium catalys
Zinc borohydride reduction of α-amino ketones: A highly diastereoselective synthetic route to anti-γ-hydroxy-β-amino alcohols
Sengupta,Das,Mondal
, p. 1464 - 1466 (2007/10/03)
A highly diastereoselective synthesis of anti-γ-hydroxy β-amino alcohols via Zn(BH4)2 reductions of serine derived α-amino ketones is described. The latter were prepared from a serine derived γ-amino-β-ketosulfone via a α-alkylation-
α-Amino Acids as Chiral Educts for Asymmetric Products. Amino Acylation with N-Acylamino Acids
Buckley, Thomas F.,Rapoport, Henry
, p. 6157 - 6163 (2007/10/02)
α-N-Acylamino acids have been developed as useful reagents for the preparation of optically pure α-aminoalkylaryl ketones.Protection of the amino group as either the ethoxycarbonyl or benzenesulfonyl derivative allows alanine to serve as an effective educt for the chirally specific synthesis of a variety of structures containing the phenylethylamine backbone.Benzene undergoes Friedel-Crafts acylation with the N-acylalanine acid chloride.Catalyst complexation with oxagenated aromatics, however, prohibits acylation of aryl ethers.An arylmetallo reaction scheme overcomes this problem and also affords regiospecificity not attainable in conventional acylations.As examples, optically pure ephedrines and amphetamines were directly synthesized without recourse to resolution since the chirality of the amino acid educt was entirely conserved throughout the process.
