79297-23-7

Upstream product

• 873-66-5 1-propenylbenzene 
• 118-52-5 1,3-dichloro-5,5-dimethylhydantoin 
• 51-79-6 urethane 
• 79219-15-1 (S)-2-<(ethoxycarbonyl)amino>-1-phenyl-1-propanone 

Downstream Products

• 29238-31-1 α--propiophenon 
• 301307-97-1 5(S)-methyl-4(S)-phenyl-oxazolidin-2-one 
• 492-41-1 (1R,2S)-norephedrine 
• 492-39-7 (1S,2S)-2-amino-1-phenylpropanol 
• 299-42-3 ephedrine 
• 90-82-4 pseudoephedrine 
• 16251-45-9 (4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one 
• 182051-38-3 (2S,4S,5R)-2-(2'-bromoethyl)-N-ethoxycarbonyl-5-phenyl-4-methyl-1,3-oxazolidine 

Relevant academic research and scientific papers

Process for preparing β-hydroxycarbamates and their conversion to oxazolidinones

A process for preparing a β-hydroxy carbamate product is disclosed. The process comprises reacting an olefin compound containing at least one carbon-carbon double bond with a carbamate in an aqueous solvent and in the presence of a base, an osmium catalys

Zinc borohydride reduction of α-amino ketones: A highly diastereoselective synthetic route to anti-γ-hydroxy-β-amino alcohols

A highly diastereoselective synthesis of anti-γ-hydroxy β-amino alcohols via Zn(BH4)2 reductions of serine derived α-amino ketones is described. The latter were prepared from a serine derived γ-amino-β-ketosulfone via a α-alkylation-

Erythro-Directive Reduction of α-Substituted Alkanones by Means of Hydrosilanes in Acidic Media

Hydrosilane reduced α-oxy and α-amino ketones and β-keto acid derivatives in trifluoroacetic acid to afford the corresponding erythro alcohols with high diastereoselectivity.The reaction proceeded without racemization at the carbon α to the carbonyl group.The erythro-directive reduction was explained in terms of the proton-bridged Cram cyclic model and successfully applied to the synthesis of physiologically important amino alcohols such as l-ephedrine, l-methoxamine, and erythro-2-methyl-3-piperidino-1-phenylpropanol.

α-Amino Acids as Chiral Educts for Asymmetric Products. Amino Acylation with N-Acylamino Acids

α-N-Acylamino acids have been developed as useful reagents for the preparation of optically pure α-aminoalkylaryl ketones.Protection of the amino group as either the ethoxycarbonyl or benzenesulfonyl derivative allows alanine to serve as an effective educt for the chirally specific synthesis of a variety of structures containing the phenylethylamine backbone.Benzene undergoes Friedel-Crafts acylation with the N-acylalanine acid chloride.Catalyst complexation with oxagenated aromatics, however, prohibits acylation of aryl ethers.An arylmetallo reaction scheme overcomes this problem and also affords regiospecificity not attainable in conventional acylations.As examples, optically pure ephedrines and amphetamines were directly synthesized without recourse to resolution since the chirality of the amino acid educt was entirely conserved throughout the process.