79299-77-7

Basic information

• Product Name: 9-cis-Retinyl Stearate
• Synonyms: 9-cis-Retinyl Stearate
• CAS NO: 79299-77-7
• Molecular Formula: C38H64O2
• Molecular Weight: 552.91356
• Product Categories: Fatty Acid Derivatives & Lipids;Glycerols;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Retinoids
• Mol File: 79299-77-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Amber Vial, -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• CAS DataBase Reference: 9-cis-Retinyl Stearate(CAS DataBase Reference)
• NIST Chemistry Reference: 9-cis-Retinyl Stearate(79299-77-7)
• EPA Substance Registry System: 9-cis-Retinyl Stearate(79299-77-7)

Safety Data

• Hazardous Substances Data: 79299-77-7(Hazardous Substances Data)

Usage

Description

9-cis-Retinyl Stearate, also known as R275600, is a fatty acid ester of the retinol isomer found predominantly in the retina. It plays a crucial role in maintaining the health and function of the retina, as well as contributing to the overall health of the eye.

Uses

Used in Pharmaceutical Industry:
9-cis-Retinyl Stearate is used as a therapeutic agent for the treatment and prevention of various eye disorders, particularly those affecting the retina. Its presence in the retina suggests its potential role in maintaining retinal health and function.
Used in Nutritional Supplements:
9-cis-Retinyl Stearate is used as a nutritional supplement to support eye health and promote overall ocular well-being. It can be found in formulations designed to address age-related macular degeneration, dry eye syndrome, and other conditions that impact vision and eye health.
Used in Cosmetic Industry:
9-cis-Retinyl Stearate is used as an ingredient in cosmetic products, particularly those targeting the delicate skin around the eyes. Its potential benefits for eye health and skin rejuvenation make it a valuable addition to anti-aging and skincare formulations.

Upstream product

• 110-86-1 pyridine 
• 68-26-8 RETINOL 
• 112-76-5 Stearoyl chloride 
• 127-47-9 Retinol acetate 
• 57-11-4 stearic acid 

Relevant articles and documents

An LC/MS/MS method for stable isotope dilution studies of β-carotene bioavailability, bioconversion, and vitamin A status in humans

Isotope dilution is currently the most accurate technique in humans to determine vitamin A status and bioavailability/ bioconversion of provitamin A carotenoids such as α -carotene. However, limits of MS detection, coupled with extensive isolation procedures, have hindered investigations of physiologically-relevant doses of stable isotopes in large intervention trials. Here, a sensitive liquid chromatography- tandem mass spectrometry (LC/MS/MS) analytical method was developed to study the plasma response from coadministered oral doses of 2 mg [ 13 C 10 ] α -carotene and 1 mg [ 13 C 10 ]retinyl acetate in human subjects over a 2 week period. A reverse phase C 18 column and binary mobile phase solvent system separated α -carotene, retinol, retinyl acetate, retinyl linoleate, retinyl palmitate/retinyl oleate, and retinyl stearate within a 7 min run time. Selected reaction monitoring of analytes was performed under atmospheric pressure chemical ionization in positive mode at m/z 537 ? 321 and m/z 269 ? 93 for respective [ 12 C] α -carotene and [ 12 C] retinoids; m/z 547 ? 330 and m/z 274 ? 98 for [ 13 C 10 ] α -carotene and [ 13 C 5 ] cleavage products; and m/z 279 ? 100 for metabolites of [ 13 C 10 ]retinyl acetate. A single one-phase solvent extraction, with no saponification or purification steps, left retinyl esters intact for determination of intestinally-derived retinol in chylomicrons versus retinol from the liver bound to retinol binding protein. Coadministration of [ 13 C 10 ] retinyl acetate with [ 13 C 10 ] α -carotene not only acts as a reference dose for inter-individual variations in absorption and chylomicron clearance rates, but also allows for simultaneous determination of an individual's vitamin A status. - Oxley, A., P. Berry, G. A. Taylor, J. Cowell, M. J. Hall, J. Hesketh, G. Lietz, and A. V. Boddy. An LC/MS/MS method for stable isotope dilution studies of α -carotene bioavailability, bioconversion, and vitamin A status in humans. Copyright