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(16b,17a)-Estra-1,3,5(10)-triene-3,16,17-triol, also known as trans-Estriol, is a naturally occurring metabolite of Estradiol (E888000). It is a steroid hormone with a distinct chemical structure characterized by its preferential binding affinity for human estrogen receptor beta (ERβ) over estrogen receptor alpha (ERα). This unique property makes it a potential candidate for various applications in the medical and pharmaceutical industries.

793-89-5

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793-89-5 Usage

Uses

Used in Pharmaceutical Applications:
Trans-Estriol is used as a therapeutic agent for various hormone-related conditions due to its preferential binding to ERβ. This selective action can potentially lead to fewer side effects compared to non-selective estrogen receptor agonists.
Used in Hormone Replacement Therapy (HRT):
In the field of hormone replacement therapy, trans-Estriol is used as a component to help alleviate symptoms associated with menopause, such as hot flashes and vaginal atrophy. Its selective binding to ERβ may provide a more targeted approach to treating menopausal symptoms with reduced risks.
Used in Research and Development:
Trans-Estriol is also utilized in research and development for the study of estrogen receptor function and the development of new drugs targeting specific estrogen receptor subtypes. This can lead to the creation of more effective and safer medications for a range of conditions.
Used in the Treatment of Certain Cancers:
Due to its preferential binding to ERβ, trans-Estriol may have potential applications in the treatment of certain types of cancer, particularly those that are influenced by estrogen receptor activity. Further research is needed to explore this application fully.
Used in the Development of New Drug Delivery Systems:
Similar to gallotannin, trans-Estriol's potential applications can be enhanced through the development of novel drug delivery systems. These systems could improve the bioavailability, delivery, and therapeutic outcomes of trans-Estriol, making it a more effective treatment option for various conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 793-89-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,9 and 3 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 793-89:
(5*7)+(4*9)+(3*3)+(2*8)+(1*9)=105
105 % 10 = 5
So 793-89-5 is a valid CAS Registry Number.

793-89-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (8R,9S,13S,14S,16S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

1.2 Other means of identification

Product number -
Other names 16,17-Epiestriol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:793-89-5 SDS

793-89-5Downstream Products

793-89-5Relevant academic research and scientific papers

Processes for the preparation of 16beta-alkoxy, 17alpha-hydroxy steroids and steroidal 16beta, 17alpha-diols from 16alpha, 17alpha-epoxy steroids

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Page/Page column 7, (2008/06/13)

The present invention provides processes for the preparation of 16β-alkoxy, 17α-hydroxy steroids via the reaction of a 16α,17α-epoxy steroid with an appropriate alcohol in the presence of base. The present invention also provides processes for the preparation of 16β-alkoxy, 17α-hydroxy steroids.

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