20592-42-1

Basic information

• Product Name: estra-1,3,5(10),16-tetraene-3,17-diol diacetate
• Synonyms: estra-1,3,5(10),16-tetraene-3,17-diol diacetate;3,17-Dihydroxyestra-1,3,5(10),16-tetraene3,17-diacetate;Estra-1,3,5(10),16-tetraene-3,17-diol3,17-diacetate;1,3,5(10),16-Estratetrene-3,17-diol diacetate;Estra-1,3,5(10),16-tetrene-3,17-diol diacetate;KPJNGUPMJAHAND-JBPLPALLSA-N
• CAS NO: 20592-42-1
• Molecular Formula: C₂₂H₂₆O₄
• Molecular Weight: 354.43944
• EINECS: 243-899-7
• Product Categories: Aromatics, Steroids, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 20592-42-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 490.8°Cat760mmHg
• Flash Point: 245.3°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 8.84E-10mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: estra-1,3,5(10),16-tetraene-3,17-diol diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: estra-1,3,5(10),16-tetraene-3,17-diol diacetate(20592-42-1)
• EPA Substance Registry System: estra-1,3,5(10),16-tetraene-3,17-diol diacetate(20592-42-1)

Safety Data

• Hazardous Substances Data: 20592-42-1(Hazardous Substances Data)

Usage

Uses

Estrone Enol Diacetate can be applied as a substrate for human paroxonases. A steroid with potential to be inhibitor of NADH-oxidase and succinate oxidase.

InChI:InChI=1/C22H26O4/c1-13(23)25-16-5-7-17-15(12-16)4-6-19-18(17)10-11-22(3)20(19)8-9-21(22)26-14(2)24/h5,7,9,12,18-20H,4,6,8,10-11H2,1-3H3

Upstream product

• 108-22-5 Isopropenyl acetate 
• 53-16-7 Estrone 

Downstream Products

• 1247-70-7 3,16β-diacetoxyestra-1,3,5(10)-trien-17-one 
• 69744-63-4 3,17β-diacetoxy-16α,17α-epoxy-estra-1,3,5(10)-triene 
• 1235454-72-4 (8S,9S,13S,14S)-13-Methyl-17-phenyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-3-ol 
• 472-57-1 3-Hydroxyestra-1,3,5(10)-triene 16β,17β-Oxide 
• 1225-58-7 1,3,5(10)-Estratriene-3,16β-diol 
• 793-89-5 16,17-Epiestriol 
• 50-27-1 Estriol 
• 966-06-3 16beta-Hydroxyestrone 
• 547-81-9 epiestriol 
• 77862-30-7 16α-(Phenylseleno)estra-1,3,5(10)-trien-3-ol-17-one 
• 54982-79-5 16alpha-Bromo-17beta-estradiol 
• 71765-95-2 16alpha-Bromoestrone 
• 92817-10-2 16alpha-Fluoroestradiol 
• 92817-11-3 16α-Fluoroestra-1,3,5(10)-triene-3,17α-diol 

Relevant articles and documents

Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase

The conversion of estrone to 14,15-secoestratrien-15-ynes, inactivators of estradiol dehydrogenase from human term placenta, is described.The optically pure precursor 7-acetoxy-octahydro-2-phenanthrenecarboxylic acid methyl ester is prepared from estrone

STEREOSELECTIVE REDUCTION OF ALPHA-HYDROXYKETONE

The present invention provides methods for 1, 2-asymmetric reduction of other compounds wherein 1,2- trans diol is present. In particular the present invention discloses preparation of 17β-Estriol and its derivatives having substantially free of 17α-Estriol impurity using an achiral reductant sodium triacetoxy borohydride.

Synthesis of 16α- and 16β-fluoro-17β-estradiol by fluorination of estrone enols

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