20592-42-1

Usage

Uses

Used in Pharmaceutical Industry:
Estra-1,3,5(10),16-tetraene-3,17-diol diacetate is used as a substrate for human paroxonases, enzymes that play a crucial role in the detoxification of various harmful substances in the body. Its ability to modulate the activity of these enzymes can have significant implications in the development of therapeutic agents for various diseases.
Used in Biochemical Research:
Estra-1,3,5(10),16-tetraene-3,17-diol diacetate has the potential to be an inhibitor of NADH-oxidase and succinate oxidase, key enzymes involved in cellular respiration and energy production. Its inhibitory effects on these enzymes can be valuable in studying the mechanisms of cellular metabolism and the development of drugs targeting metabolic disorders.

InChI:InChI=1/C22H26O4/c1-13(23)25-16-5-7-17-15(12-16)4-6-19-18(17)10-11-22(3)20(19)8-9-21(22)26-14(2)24/h5,7,9,12,18-20H,4,6,8,10-11H2,1-3H3

Upstream product

• 108-22-5 Isopropenyl acetate 
• 53-16-7 Estrone 

Downstream Products

• 71765-95-2 16alpha-Bromoestrone 
• 54982-79-5 16alpha-Bromo-17beta-estradiol 
• 77862-30-7 16α-(Phenylseleno)estra-1,3,5(10)-trien-3-ol-17-one 
• 1235454-72-4 (8S,9S,13S,14S)-13-Methyl-17-phenyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-3-ol 
• 472-57-1 3-Hydroxyestra-1,3,5(10)-triene 16β,17β-Oxide 
• 1225-58-7 1,3,5(10)-Estratriene-3,16β-diol 
• 793-89-5 16,17-Epiestriol 
• 50-27-1 Estriol 
• 966-06-3 16beta-Hydroxyestrone 
• 547-81-9 epiestriol 
• 1247-70-7 3,16β-diacetoxyestra-1,3,5(10)-trien-17-one 
• 92817-10-2 16alpha-Fluoroestradiol 
• 92817-11-3 16α-Fluoroestra-1,3,5(10)-triene-3,17α-diol 
• 78149-55-0 16α-(Phenylseleno)estrone Acetate 

Relevant academic research and scientific papers

Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase

The conversion of estrone to 14,15-secoestratrien-15-ynes, inactivators of estradiol dehydrogenase from human term placenta, is described.The optically pure precursor 7-acetoxy-octahydro-2-phenanthrenecarboxylic acid methyl ester is prepared from estrone

PROCESS FOR THE PRODUCTION OF ESTETROL INTERMEDIATES

The present invention relates to a process for the preparation of a compound of formula (I) said process comprising the steps of : a) reacting a compound of formula (II), with an acylating or a silylating agent to produce a compound of formula (III), wher

STEREOSELECTIVE REDUCTION OF ALPHA-HYDROXYKETONE

The present invention provides methods for 1, 2-asymmetric reduction of other compounds wherein 1,2- trans diol is present. In particular the present invention discloses preparation of 17β-Estriol and its derivatives having substantially free of 17α-Estriol impurity using an achiral reductant sodium triacetoxy borohydride.

Construction of polysubstituted olefins through Ni-Catalyzed direct activation of Alkenyl C-O of substituted alkenyl acetates

(Figure Presented) Reliable companion: For the first time cross-coupling between alkenyl acetates and arylboroxines/PhZnCl has been developed via Ni catalysis. Alkenyl acetates could be well-differ-entiated from aryl acetates (see scheme). This reliable method provides a convenient pathway to construct polysubstituted styrene derivatives.