79313-01-2Relevant articles and documents
A highly selective chemodosimeter for fast detection and intracellular imaging of Hg2+ ions based on a dithiocarbamate-isothiocyanate conversion in aqueous ethanol
Pal, Suman,Hatai, Joydev,Samanta, Mousumi,Shaurya, Alok,Bandyopadhyay, Subhajit
, p. 1072 - 1078 (2014)
A new naphthalene diimide-dithiocarbamate based fluorescence probe was synthesized and its fluorogenic behavior towards various metal ions was studied. Upon addition of various metal ions, the probe afforded an irreversible change only with Hg2+ ions in aqueous-ethanol media (4:1 v/v) with a fourfold enhancement of the fluorescence (Φ = 0.03 → 0.11) along with a distinct 43 nm blue shift of the emission maxima. The mechanism of the chemodosimetric behavior of the probe has been attributed to a Hg2+ induced transformation of a weakly fluorescent dithiocarbamate to a highly fluorescent isothiocyanate which has been characterized by a number of spectroscopic techniques and a crystal structure. Intracellular detection of Hg2+ ions was achieved using the probe. The Royal Society of Chemistry.
Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
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Page column 145, (2010/02/07)
Pharmaceutical compositions containing an FBPase inhibitor and an insulin sensitizer are provided as well as methods for treating diabetes and diseases responding to increased glycemic control, an improvement in insulin sensitivity, a reduction in insulin levels, or an enhancement of insulin secretion.
Heteroaromatic compounds containing a phosphonate group that are inhibitors of fructose-1,6-bisphosphatase
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, (2008/06/13)
FBPase inhibitors of the formula I and X are useful in the treatment of diabetes and other conditions associated with elevated blood glucose or excess glycogen storage.