79322-92-2

Usage

Properties

1. Chemical compound
2. Belongs to the piperazine class of chemicals
3. Potential treatment for central nervous system disorders
4. Dopamine D3 receptor antagonist
5. Investigated for treating substance use disorders

Also known as

BMS-826476
Studied for potential use in treating schizophrenia and bipolar disorder
Acts as a potent and selective dopamine D3 receptor antagonist
Investigated for potential use in treating substance use disorders
Further research needed to understand its potential therapeutic applications and safety profile

Upstream product

• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 107-13-1 acrylonitrile 

Downstream Products

• 79322-93-3 3-[4-(4-chlorophenyl)piperazin-1-yl]propan-1-amine 
• 740831-44-1 1-(4-chlorophenyl)-4-[2-(1H-tetrazol-5-yl)-ethyl]-piperazine 
• 79323-07-2 1-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-propyl}-4-(4-methoxy-phenyl)-piperidine-2,6-dione 

Relevant academic research and scientific papers

Molecular interactions between carbon nanotubes and ammonium ionic liquids and their catalysis properties

A new catalytic method has been developed for the synthesis of aza/thia-Michael addition reactions of amines/thiols, which provide higher product yields. This catalyst is a combination of multi-walled carbon nanotubes (MWCNT) with triethylammonium hydroge

Single-walled carbon nanotube-triethylammonium ionic liquid as a new catalytic system for Michael reaction

A new efficient catalytic method for aza/thia-Michael addition reactions of amines/thiols with higher product yields has been developed. Combining single-walled carbon nanotubes (SWCNT) with triethylammonium hydrogen phosphate (TEAP) ionic liquid (IL) can

Triethylammonium acetate (TEAA): A recyclable inexpensive ionic liquid promotes the chemoselective aza- and thia-Michael reactions

A new, highly efficient, inexpensive, recyclable, mild, convenient, and green protocol for chemoselective aza/thia-Michael addition reactions of amines/thiols to α,β-unsaturated compounds using triethylammonium acetate (TEAA) ionic liquid was developed. The catalyst can be recycled ten times and obviate the need for toxic and expensive catalysts.

Optically active antifungal azoles: Synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]-ethyl} -tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol

A series of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]- ethyl}-tetrazol-2-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol (11a-n) and (2R,3S)-2-(2,4-difluorophenyl)-3-(5-{2-[4-aryl-piperazin-1-yl]-ethyl} -tetrazole-1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol (12a-n) has been synthesized. The antifungal activity of compounds was evaluated by in vitro agar diffusion and broth dilution assay. Compounds 11d and its positional isomer 12d having 3-trifluoromethyl substitution on the phenyl ring of piperazine demonstrated significant antifungal activity against variety of fungal cultures (Candida spp. C. neoformans and Aspergillus spp.). The compound 12d showed MIC value of 0.12μg/mL for C. albicans, C. albicans V-01-191A-261 (resistant strain); 0.25μg/mL for C. tropicalis, C. parapsilosis ATCC 22019 and C. krusei and MIC value of 0.5μg/mL for C. glabrata, C. krusei ATCC 6258, which is comparable to itraconazole and better than fluconazole. Further, compound 11d showed significant activity (MIC; 0.25-0.5μg/mL) against Candida spp. and strong anticryptococcal activity (MIC; 0.25μg/mL) against C. neoformans.