79324-94-0Relevant academic research and scientific papers
Assembly of substituted 1H-benzimidazoles and 1,3-dihydrobenzimidazol-2- ones via CuI/L-proline catalyzed coupling of aqueous ammonia with 2-iodoacetanilides and 2-iodophenylcarbamates
Diao, Xiaoqiong,Wang, Yuji,Jiang, Yongwen,Ma, Dawei
scheme or table, p. 7974 - 7977 (2010/02/28)
(Chemical Equation Presented) CuI/L-proline catalyzed coupling of aqueous ammonia with 2-iodoacetanilides and 2-iodophenylcarbamates affords the aryl amination products at room temperature, which undergo in situ additive cyclization under acidic conditions or heating to give substituted 1H-benzimidazoles and 1,3-dihydrobenzimidazol-2-ones, respectively. A wide range of functional groups including ketone, nitro, iodo, bromo, and ester are tolerated under these reaction conditions, providing these heterocycles with great diversity.
INVESTIGATION OF THE REACTION OF FURFURAL WITH o-PHENYLEDIAMINES
Burmistrov, S. I.,Sannikova, V. M.
, p. 606 - 609 (2007/10/02)
1,2-Disubstituted benzimidazoles were synthesized by the reaction of furfural and 5-methylfurfural with o-phenylenediamines in an alcoholic acidic medium.
