79333-82-7

Basic information

• Product Name: diethyl [3-(dimethylamino)propyl]phosphonate
• CAS NO: 79333-82-7
• Molecular Formula: C₉H₂₂NO₃P
• Molecular Weight: 223.2496
• Mol File: 79333-82-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 283.2°C at 760 mmHg
• Flash Point: 125.1°C
• Density: 1.009g/cm³
• Vapor Pressure: 0.0032mmHg at 25°C
• Refractive Index: 1.435
• CAS DataBase Reference: diethyl [3-(dimethylamino)propyl]phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl [3-(dimethylamino)propyl]phosphonate(79333-82-7)
• EPA Substance Registry System: diethyl [3-(dimethylamino)propyl]phosphonate(79333-82-7)

Safety Data

• Hazardous Substances Data: 79333-82-7(Hazardous Substances Data)

Upstream product

• 3986-95-6 diethyl (3-oxopropyl)phosphonate 
• 124-40-3 dimethyl amine 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 122-52-1 triethyl phosphite 
• 2303-76-6 sodium diethyl phosphite 
• 23269-98-9 diethyl (3-chloropropyl)phosphonate 

Downstream Products

• 1668-19-5 doxepin 

Relevant articles and documents

Synthesis method of doxepin hydrochloride

The invention relates to a synthetic method of doxepin hydrochloride. The method comprises the following steps: (1) phosphites react with 3 - chlorine -1 - (N, N - dimethyl) propylamine to obtain 3 - (N, N - dimethyl) propyl phosphate, or a salt thereof with hydrochloric acid to obtain 3 - (N, N - dimethyl) propyl phosphate hydrochloride. (2) Reaction of 3 - (N, N -dimethyl) propyl phosphate or its hydrochloride with 6, 11 -dihydrodibenzo [b, e] oxepin -11 - ketone under strong base conditions Wittig to obtain doxorubicin. (3) The multi-plug is subjected to salt formation reaction with hydrochloric acid to prepare the doxorubicin hydrochloride. In 1st-step reaction step, the yield of the alkyl phosphate product prepared by adopting the reaction is high, thereby ensuring the yield and purity of the final product hydrochloride. Compared with the prior art, the method has the advantages of simple process, low production cost, less process steps and the like.

Catalytic Hydrogenation for Producing Amines from Carboxylic Acid Amides, Carboxylic Acid Diamides, Di-, Tri-, or Polypeptides, or Peptide Amides

The present invention relates to a process for the preparation of amines, comprising the following steps: a. reaction of a (i) carboxylic acid amide of the general formula (I), or (ii) carboxylic acid diamide of the general formula (II), or (iii) di-, tri- or polypeptide, or (iv) peptide amide with carboxy-terminal amide function with an alkylating agent, b. addition of a hydrogenation catalyst to the reaction mixture in a molar ratio of from 1:10 to 1:100 000, based on carboxylic acid amide, carboxylic acid diamide, di-, tri- or polypeptide or peptide amide, c. reaction of the reaction mixture with hydrogen, where a hydrogen pressure of from 0.1 bar to 200 bar is established and where a temperature in a range of from 0° C. to 250° C. is established.

Phosphorus analogs of nitrogenous drugs. II. 10H-Dibenzo[1,4]thiaphosphorins as central nervous system depressants.

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