79355-23-0

Upstream product

• 17283-81-7 4-(2,6,6-Trimethyl-cyclohex-1-enyl)-butan-2-on 
• 6040-06-8 (4E,8E,12E)-5,9,13-trimethyl-4,8,12-tetradecatrienoic acid 
• 99733-97-8 3-methyl-5-(2',6',6'-trimethylcyclohex-1'-enyl)-1-penten-3-ol 
• 108893-76-1 cis-β-Monocyclofarnesylacetic acid 
• 468-84-8 ambreinolide 

Downstream Products

• 473-03-0 (+)-ambreine 
• 473-03-0 (17R)-ambrein 
• 10281-49-9 2-{(1S,2R,4aR,8aS)-1-[(E)-6-(2,2-Dimethyl-6-methylene-cyclohexyl)-4-methyl-hex-3-enyl]-2,5,5,8a-tetramethyl-decahydro-naphthalen-2-yloxy}-tetrahydro-pyran 
• 87553-46-6 (+/-)-(4aS,4bS,8aS)-2,4b,8,8-tetramethyl-1,2,3,4,4a,4b,5,6,7,8,8a,9-dodecahydrophenathrene-2-ol 

Relevant academic research and scientific papers

Total synthesis of (+/-)-syn-copalol.

The labdane diterpene derivative, syn-copalol [(+)-5] is the alcohol part of syn-copalyl diphosphate [(+)-4]. In this paper, racemic (+/-)-5 was synthesized from a known racemic lactone in 8 steps. The current and our previous syntheses provide all four copalol derivatives [(+)-3, (-)-3 and (+/-)-5] which are required for the biosynthetic study of polycyclic diterpenes.

New Syntheses of (+/-)-Ambrox, (+/-)-Ambra Oxide and Their Stereoisomers

New and efficient syntheses of (+/-)-ambrox (1a), (+/-)-ambra oxide (2a) and their stereoisomers (1b, 2b ca. c), amber-like odorous compounds, are described.Starting from dihydro β- and α-ionone (5,12), these substances were obtained in only a few steps via stereoselective acid-catalized cyclization of monocyclodienoic acid (7a ca. b, 11a ca. b, 15a).