79359-36-7

Upstream product

• 2700-22-3 Benzylidenemalononitrile 
• 137-07-5 2-amino-benzenethiol 
• 100-52-7 benzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 67720-42-7 2-hydroxy-6-amino-4-phenylpyridine-3,5-dicarbonitrile 

Relevant academic research and scientific papers

System and method for preparing 6-mercapto polysubstituted pyridine derivative through three-component one-pot reaction

The invention discloses a system and method for preparing a 6-mercapto polysubstituted pyridine derivative through a three-component one-pot reaction, belonging to the technical field of organic synthesis. The preparation system for the 6-mercapto polysubstituted pyridine derivative comprises a raw material mixing device, a microwave reaction device, a suction filtration device, a washing device and a vacuum drying device which are sequentially arranged, wherein the microwave reaction device is used for a microwave heating reaction of raw materials in the raw material mixing device; the suction filtration device is used for suction filtration of a reaction product; the washing device and the vacuum drying device are used for washing and vacuum drying of a filter residue obtained after filtering, respectively. According to the invention, aromatic aldehydes, malononitrile and mercapto compounds are used as reaction materials, and the 6-mercapto polysubstituted pyridine derivative is prepared under the catalysis of an alkaline ionic liquid catalyst. The catalyst used in the invention is high in catalytic activity and low in usage amount and cyclic loss; and the prepared derivate has high yield and high purity.

K2CO3 catalyzed green and rapid access to 2-amino-3,5-dicarbonitrile-6-thio-pyridines

A series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized by a simple method via a one-pot, three-component condensation reaction of aromatic aldehydes and malononitrile with substituted thiophenols using potassium carbonate as a green base in polyethylene glycol (PEG-400) as a reusable solvent. This protocol proved to be efficient and environmentally benign in terms of high yields, short reaction times, mild conditions, and reusability of the reaction medium.

Synthesis of 2-amino-4-phenyl-6-(phenylsulfanyl)-3,5-dicyanopyridines by tandem reaction

A novel basic ionic liquid, 1-(2-aminoethyl)pyridinium hydroxide, containing both Bronsted base and Lewis base sites has been used as an efficient catalyst for the synthesis of 2-amino-4-phenyl-6-(phenylsulfanyl)-3,5- dicyanopyridines. The condensation and oxidation tandem reaction of aldehydes, malononitrile, and thiols, performed in aqueous ethanol, afforded reasonable to good yields within 30-60 min. After the reaction, the catalyst could be recycled and reused. A possible mechanism to account for the tandem reaction is proposed. Graphical abstract: [Figure not available: see fulltext.].

Scandium triflate-catalyzed one-pot multi-component synthesis of 2-amino-6-thiopyridine-3,5-dicarbonitriles

Scandium triflate efficiently promotes a one-pot, three-component condensation of aldehydes, malononitrile, and thiophenols to produce highly substituted pyridines in good yields. This reaction does not involve any hazardous organic solvent and toxic cata

Facile and rapid access to poly functionalized pyridine derivatives

An efficient and greener protocol for the synthesis of poly functionalized pyridines using tetra-n-butyl ammonium fluoride (TBAF) in water is established. Remarkable advantages of the present synthetic strategy over the others are shorter reaction times,

Aqueous suspension of basic alumina: An efficient catalytic system for the synthesis of poly functionalized pyridines

In the present work, catalytic activity of basic alumina in water has been demonstrated for the synthesis of poly functionalized pyridines. This strategy has some remarkable advantages, such as use of heterogeneous catalyst in aqueous media, reusability o

Application of unmodified microporous molecular sieves for the synthesis of poly functionalized pyridine derivatives in water

In the present work, catalytic activity of acidic as well as basic sites present over the microporous molecular sieves has been demonstrated. These acid-base sites display the combined catalytic reactivity in tap/deionized water for the efficient synthesi

Boric acid catalyzed convenient synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines in aqueous media

A one-pot three-component condensation of an aldehyde, malononitrile, and thiophenol has been achieved by conventional and ultrasound method. The reaction has been catalyzed by boric acid in aqueous medium. This protocol afforded corresponding 2-amino-3,5

An efficient procedure for the synthesis of substituted pyridines using KF·Al2O3

(Chemical Equation Presented) Three-component coupling of aldehydes, malononitrile, and thiophenols has efficiently been carried out at room temperature using potassium fluoride on alumina (KF·Al2O 3) as a catalyst to furnish highly substituted pyridines in high yields.

An improved procedure for the three-component synthesis of highly substituted pyridines using ionic liquid

(Chemical Equation Presented) A basic ionic liquid, [bmIm]OH, efficiently promotes a one-pot, three-component condensation of aldehydes, malononitrile, and thiophenols to produce highly substituted pyridines in high yields at room temperature. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid is recovered and recycled for subsequent reactions.