79367-52-5 Usage
Enzyme inhibitor
These sphingoid-like alkaloids (AAL Toxin TA1; FW = 521.64 g/mL; CAS 79367-52-5; AAL Toxin TA2; FW = 521.65 g/mol; CAS 79367-51-4) from the ascomycete fungus Alternaria alternata inhibit ceramide synthase, an early biochemical event in the animal diseases associated with consumption of Fusarium moniliforme-contaminated corn. Because free sphingoid bases are precursors to plant “ceramides,” their accumulation suggests that the primary biochemical lesion is inhibition of de novo ceramide synthesis and re-acylation of free sphingoid bases. Target(s): ceramide synthase, or sphingosine N-acyltransferase.
Check Digit Verification of cas no
The CAS Registry Mumber 79367-52-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,3,6 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 79367-52:
(7*7)+(6*9)+(5*3)+(4*6)+(3*7)+(2*5)+(1*2)=175
175 % 10 = 5
So 79367-52-5 is a valid CAS Registry Number.
InChI:InChI=1/C25H47NO10/c1-4-15(3)23(32)17(22(25(35)36)18(24(33)34)12-21(30)31)10-14(2)8-6-5-7-9-19(28)20(29)11-16(27)13-26/h14-20,22-23,27-29,32H,4-13,26H2,1-3H3,(H,30,31)(H,33,34)(H,35,36)/t14-,15+,16-,17?,18+,19+,20-,22?,23+/m0/s1
79367-52-5Relevant articles and documents
Total synthesis of AAL-toxin TA1
Oikawa, Hideaki,Yamawaki, Daisuke,Kagawa, Takashi,Ichihara, Akitami
, p. 6621 - 6625 (1999)
Two alternative synthetic routes of the left-half segment 5 have been developed. Efficient condensation between the left and right segments followed by Pd-catalyzed deoxygenation and further elaboration achieved the first total synthesis of AAL-toxin TAs
