793691-64-2Relevant academic research and scientific papers
Synthesis and evaluation of novel 4-substituted styryl quinazolines as potential antimicrobial agents
Modh, Rahul P.,Patel, Amit C.,Mahajan, Dharmesh H.,Pannecouque, Christophe,De Clercq, Erik,Chikhalia, Kishor H.
, p. 964 - 972 (2013/02/22)
In an attempt to afford possible antibacterial and anti-human immunodeficiency virus (HIV) agents, a series of 22 novel styryl quinazoline-based heterocyclic entities were designed and synthesized. Various substituted aryl urea and thiourea cores were incorporated at position 4 of quinazoline, followed by styrylation of position 2, aiming at an augmented biological potential. The synthesized compounds were well characterized through IR, 1H NMR, 13C NMR and elemental analyses. All compounds were screened for their in vitro anti-HIV activity against the HIV-1 (IIIB) and HIV-2 (ROD) strains. The antibacterial activity was also evaluated against various pathogenic Gram-positive and Gram-negative bacterial strains. A series of 22 novel styryl quinazoline-based heterocyclic entities were designed and synthesized to afford possible antibacterial and anti-human immunodeficiency virus (HIV) agents. All of the prepared compounds were screened for their in vitro anti-HIV activity against the HIV-1 (IIIB) and HIV-2 (ROD) strains. The antibacterial activity was also evaluated against various pathogenic Gram-positive and Gram-negative bacterial strains. Copyright
