79379-49-0

Basic information

• Product Name: 2-Phenyl-1,4,5,6,7,8-hexahydro-cyclohepta[b]pyrrole
• Synonyms: 2-Phenyl-1,4,5,6,7,8-hexahydro-cyclohepta[b]pyrrole
• CAS NO: 79379-49-0
• Molecular Weight: 211.307
• Mol File: 79379-49-0.mol

Chemical Properties

• CAS DataBase Reference: 2-Phenyl-1,4,5,6,7,8-hexahydro-cyclohepta[b]pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-1,4,5,6,7,8-hexahydro-cyclohepta[b]pyrrole(79379-49-0)
• EPA Substance Registry System: 2-Phenyl-1,4,5,6,7,8-hexahydro-cyclohepta[b]pyrrole(79379-49-0)

Safety Data

• Hazardous Substances Data: 79379-49-0(Hazardous Substances Data)

Upstream product

• 29441-70-1 9a-morpholin-4-yl-3-phenyl-4,4a,5,6,7,8,9,9a-octahydro-cyclohepta[e][1,2]oxazine 
• 16717-64-9 1-azidostyrene 
• 15419-61-1 2-acetylcycloheptanone 
• 7182-08-3 4-(1-cyclohepten-1-yl)morpholine 
• 14181-72-7 2-bromo-1-phenyl-ethanone oxime 
• 1056246-49-1 2-bromocycloheptanone 
• 107170-78-5 <(1-phenylvinyl)imino>tributylphosphorane 
• 103896-55-5 N-(1-Phenylvinylimino)triphenylphosphorane 

Downstream Products

• 344445-95-0 2-Phenyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]pyrrol-8a-ol 
• 344441-26-5 2-Phenyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]pyrrol-8a-yl-hydroperoxide 
• 86700-14-3 (Z)-10-Phenyl-4,5,6,7-tetrahydro-1H,3H-azecine-2,8-dione 

Relevant articles and documents

Manganese(III)-catalyzed formal [3+2] annulation of vinyl azides and ?-keto acids for synthesis of pyrroles

Manganese(III)-catalyzed formal [3+2] annnulation of vinyl azides and -keto acids has been developed for the synthesis of substituted NH pyrroles with a wide range of substituents. Georg Thieme Verlag Stuttgart.

Synthesis of Pyrrole Derivatives from 5,6-Dihydro-4H-1,2-oxazines via Reductive Deoxygenation by Use of Fe3(CO)12

α-Bromooximes such as α-bromoacetophenone oxime and ethyl 3-bromo-2-(hydroxyimino)propanoate react with enamines to give 5,6-dihydro-4H-1,2-oxazines in good yields.Dihydro-1,2-oxazine derivatives are also obtained by the reaction of α-bromooximes with vinyl ethers and silyl enol ethers in the presence of Na2CO3.Dihydro-1,2-oxazines can be converted into pyrrole derivatives via reductive deoxygenation by treating with Fe3(CO)12 in moderate to excellent yields.Iron carbonyl complexes other than Fe3(CO)12 are also effective for the pyrrole-forming reaction.The efficiency of the complexes for this reaction decreases in the or der: Fe3(CO)12 >> Et3NH > Fe2(CO)9 >> Fe(CO)5.Both of the dihydro-1,2-oxazine- and pyrrole-forming reactions can be carried out in a single flask, giving pyrrole derivatives in good yields.

ON THE REACTION OF N-VINYLIMINOPHOSPHORANES 3. A NOVEL ROUTE TO PHENYL-SUBSTITUTED PYRROLES BY THE REACTION OF N-(1-PHENYLVINYL)-IMINOPHOSPHORANES WITH α-BROMO KETONES

N-(1-phenylvinyl)iminotriphenylphosphorane or N-(1-phenyl-vinyl)iminotributylphosphorane reacted with α-bromo ketones to give phenyl-substituted pyrroles via a novel C-C bond formation followed by aza-Wittig reaction.

SYNTHESIS OF PYRROLE DERIVATIVES VIA DEOXYGENATION OF 4H-1,2-OXAZINES BY IRON CARBONYLS

The reaction of 5,6-dihydro-4H-1,2-oxazines, which are derived from α-bromooximes and enamines, with iron carbonyl complexes such as Fe3(CO)12 and (C2H5)3NH gives pyrrole derivatives in high yields, accompaning deoxygenation from the oxazines.