79379-87-6

Upstream product

• 36288-37-6 N-hydroxy-4-methylbenzenecarboximidoyl chloride 
• 105-45-3 acetoacetic acid methyl ester 
• 73967-70-1 methyl 3-(isopropylamino)but-2-enoate 

Downstream Products

• 91569-59-4 3-(4-tolyl)-5-methylisoxazole-4-carboxylic acid 
• 1018297-60-3 (5-methyl-3-p-tolyl-isoxazol-4-yl)-methanol 
• 635680-03-4 5-methyl-3-p-tolyl-isoxazole-4-carbaldehyde 
• 627882-16-0 2-{hydroxy-[5-methyl-3-(4-methylphenyl)isoxazol-4-yl]methyl}acrylic acid methyl ester 
• 96448-16-7 5-methyl-3-p-tolyl-isoxazole-4-carboxylic acid amide 

Relevant academic research and scientific papers

Catalyst- and solvent-free mechanochemical synthesis of isoxazoles from N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds

A regioselective, solvent-free and catalyst-free synthesis of isoxazoles has been successfully developed under ball milling conditions. Milling the mixtures of N-hydroxybenzimidoyl chlorides and enamino carbonyl compounds in a ball mill at a frequency of

Highly substituted isoxazoles: The Baylis-Hillman reaction of substituted 4-isoxazolecarbaldehydes and attempted cyclization to isoxazole-annulated derivatives

In an attempt to understand the effect of position of the formyl group on the efficiency of Baylis-Hillman reaction within isoxazolecarbaldehydes, the reactions of substituted 4-isoxazolecarbaldehydes to obtain highly substituted isoxazoles are described. Attempts to obtain isoxazole-annulated derivatives from these Baylis-Hillman adducts involving SNR′-SNAr substitution strategy are also described.