79390-05-9Relevant academic research and scientific papers
Protein-Induced Supramolecular Disassembly of Amphiphilic Polypeptide Nanoassemblies
Molla, Mijanur Rahaman,Prasad, Priyaa,Thayumanavan
, p. 7286 - 7289 (2015)
Mimicking noncovalent interaction based processes in nature has been an important goal of supramolecular chemistry. Here, we report on amphiphilic polypeptides that self-assemble to form nanoscale supramolecular assemblies and are programmed to disassemble in response to a specific protein. Benzenesulfonamide and carbonic anhydrase have been chosen as the ligand and protein, respectively, to demonstrate this possibility. Since the amphiphilic nanoassembly sequesters hydrophobic guest molecules, the protein-specific disassembly event provides a protein-sensitive molecular release as well. We envision that the binding induced disassembly and guest release might open up new opportunities for the next generation of supramolecular assemblies for protein-specific delivery and diagnostics.
Compositions and methods of increasing renal blood flow with gamma-glutamyl amide of dopamine
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, (2008/06/13)
Covers a γ-glutamyl amide of dopamine selected from the group consisting of EQU1 and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said γ-glutamyl amide to increase renal blood flow by administering said amide to warm-blooded mammals.
