79412-70-7Relevant academic research and scientific papers
Synthesis and SAR Studies of Isoquinoline and Tetrahydroisoquinoline Derivatives as Melatonin Receptor Ligands
Caignard, Daniel Henri,Delagrange, Philippe,Ettaoussi, Mohamed,Lebegue, Nicolas,Liberelle, Maxime,Melnyk, Patricia,Rami, Marouane,Vreulz, Brandon,Laversin, Amélie,Yous, Sa?d
, (2021/12/03)
In our constant search for new successors of agomelatine, we report herein a new series of compounds resulting from bioisosteric modulation of the naphthalene ring. The isoquinoline and tetrahydroisoquinoline derivatives were synthesized and pharmacologic
New isoquinoline compounds
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Page 5, (2010/02/08)
The invention relatests compound of formula (I): wherein: n is 1, 2 or 3, A represents a group X represents N or NR1, R2 represents an alkoxy, cycloalkyloxy or cycloalkylalkyloxy group. and medicinal products containing the same which are useful in treading or in preventing melatoninergic disorder.
3-Phenylpiperidines. Central Dopamine-Autoreceptor Stimulating Activity
Hacksell, Uli,Arvidsson, Lars-Erik,Svensson, Uno,Nilsson, J. Lars G.
, p. 1475 - 1482 (2007/10/02)
Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine have been synthesized and tested for central dopamine-autoreceptor stimulating activity.The 3-(3-hydroxyphenyl)piperidine moiety seems indispensable for high potency and selectivity.Introduction of an additional hydroxyl group into the 4-position of the aromatic ring gives a compound with dopaminergic activity but lacking selectivity for autoreceptors. 3-(3-Hydroxyphenyl)-N-n-propylpyrrolidine, 3-(3-hydroxy)-N-n-propylperhydroazepine, and 3-(3-hydroxyphenyl)quinuclidine were all inactive.The most potent compounds were the N-isopropyl-, N-n-butyl-, N-n-pentyl-, and N-phenethyl-substituted 3-(3-hydroxyphenyl)piperidine derivatives.None of the compounds investigated seemed to have central noradrenaline- or serotonin-receptor stimulating activity.
