79415-18-2

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethyl-pyridine-2-carboxylic Acid, Hydrochloride is used as a starting material for the synthesis of Clindamycin analogues, such as Pirlimycin, due to its chemical properties that facilitate the creation of these important antibiotics. These analogues are essential in the development of new drugs to combat bacterial infections, especially those resistant to existing treatments.

Upstream product

• 14906-55-9 4-ethylpyridine-1-oxide 
• 92486-38-9 2-cyano-4-ethylpyridine 

Downstream Products

• 79415-24-0 (2R,4S)-4-Ethyl-piperidine-2-carboxylic acid 
• 123811-84-7 4-ethyl-BOC-DL-homoproline 
• 123811-85-8 (2S,4R)-4-Ethyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester; compound with dicyclohexyl-amine 

Relevant academic research and scientific papers

An Improved Synthesis of Homoproline and Derivatives

An improved, general synthesis of substituted homoprolines has been developed by using readily available substituted pyridines (1).A key step in this synthetic procedure involves the known conversion of pyridine-N-oxides to 2-cyanopyridines (3) in nearly quantitative yields.The resulting nitriles are hydrolyzed to the corresponding pyridine-2-carboxylic acids (4).Subsequent reduction of the aromatic ring with PtO2/H2 gives the homoprolines (5) in good yields as racemic cis isomers.This procedure also can be utilized for the preparation of 5,6-benzohomoprolines fromthe appropriate quinoline precursors.The N-tert-butyloxycarbonyl (Boc) derivatives of these amino acids (useful intermediates for peptide synthesis) were also prepared in good yields.