79419-45-7Relevant academic research and scientific papers
Short-acting sedative hypnotic agents for anesthesia and sedation
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, (2008/06/13)
The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals.
Ester Derivatives of 2,6-Bis(1-pyrrolidinylmethyl)-4-benzamidophenol as Short-Acting Antiarrhythmic Agents. 1
Stout, David M.,Black, Lawrence A.,Barcelon-Yang, Cynthia,Matier, W. L.,Brown, Barry S.,et al.
, p. 1910 - 1913 (2007/10/02)
In an effort to find a replacement for the iv antiarrhythmic drug lidocaine having reduced systemic and central nervous system effects, activity against supraventricular as well as ventricular arrhythmias, and a biological half-life of less than 15 min, derivatives of the orally active class Ic clinical agent 2,6-bis(1-pyrrolidinylmethyl)-4-benzamidophenol, 1 (ACC-9358), were synthesized and tested.Compounds with ester groups attached to the phenyl ring were either weakly active or toxic.Replacement of the formanilide function with alkyl esters afforded compounds with antiarrhythmic activity in the range of 1.When the ester carboxyl was separated from the bis(aminomethyl)phenol by methylene units, very short half-lives were observed in human blood.In general, these compounds also had low lipophilic character.
SOFT BETA-ADRENERGIC BOLCKING AGENTS
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, (2008/06/13)
New soft β-adrenergic blocking agents, useful in the treatment or prevention of cardiovascular disorders and in the treatment of glaucoma, have the formula STR1 wherein n is an integer from 0 to 10; R is C. sub.6-C 12 cycloalkyl-C p H 2p--, C 6-C. sub.18 polycycloalkyl-C p H 2p--, C 6-C 18 polycycloalkenyl-C. sub.p H 2p--or C 6 C 12 cycloalkenyl-C. sub.p H 2p--(wherein p is 0, 1, 2 or 3), or together with the adjacent STR2 group represents a variety of other complex ester groupings; R 1 is C 1-C 7 alkyl; and Ar is a divalent radical containing at least one aromatic nucleus. The corresponding pharmaceutically acceptable acid addition salts are also described.
