79419-90-2Relevant academic research and scientific papers
Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones
Nozawa-Kumada, Kanako,Matsuzawa, Yuta,Ono, Kanako,Shigeno, Masanori,Kondo, Yoshinori
, p. 8604 - 8607 (2021/09/02)
A copper-catalyzed aerobic 3-hydroxyisoindolinone synthesis was developed via the benzylic double C(sp3)-H functionalization of 2-alkylbenzamides. In this reaction, molecular oxygen was used as both an oxidant for C(sp3)-H functionalization and an oxygen source. Our method can be extended to diverse benzylic C(sp3)-H bonds and shows excellent functional group tolerance. This journal is
Studies on the Mode of Ring-Opening of N-aryl Phthalisoimidium Perchlorates
Ismail, M. Fekry,Sayed, F. S.,Derbala, H. A. Y.,Mansour, M. M.
, p. 1114 - 1119 (2007/10/02)
N-Arylphthalisoimidium perchlorates (1a, b and 7) react with primary amines via ring-opening to give N,N'-disubstituted phthalamides (3a-c and 9a,b) respectively. (1a reacts with aromatic hydrocarbons under Friedel-Crafts conditions to give 2,3-diaryl-3-hydroxyphthalimidines (11a-c) while (1b) undergoes rearrangement to (12) via the intermediate formation of the isoimide (13) under the same reaction conditions. Key words: isoimidium salts, phthalamides, hydroxyphthalimidines
