340756-74-3

Upstream product

• 177-11-7 4,4-ethylenedioxy-piperidine 
• 655-32-3 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone 
• 79421-38-8 4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-benzoic acid ethyl ester 

Downstream Products

• 340757-08-6 [butyl(4-{4-[(2R)-2-hydroxy-2-(4-hydroxy-3-methanesulfonylaminophenyl)ethylamino]piperidin-1-yl}benzoyl)amino]acetic acid ethyl ester 
• 340757-00-8 methyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-phenylalaninate 
• 340756-99-2 ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate 
• 340756-98-1 ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-valinate 
• 340756-97-0 methyl 1-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-prolinate 
• 340756-96-9 ethyl [(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)amino]acetate 
• 340756-95-8 dibenzyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-glutamate 
• 340756-91-4 3-[4-(4-oxopiperidin-1-yl)benzoylamino]propionic acid benzyl ester 
• 340809-44-1 methyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-phenylalaninate 
• 340756-94-7 ethyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-leucinate 
• 340756-93-6 ethyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-valinate 

Relevant academic research and scientific papers

A practical method for the preparation of 4-nitrogen-substituted benzoic acids

An efficient and practical method for the preparation of 4-nitrogen-substituted benzoic acids is described. Our method consists of the aromatic substitution of 2,2,2,4′-tetrafluoroacetophenone with amines, followed by haloform reaction to the benzoic acids. In this method, even though for the less nucleophilic 7-, 8-, and 9-membered amines 1 equiv. was used, corresponding benzoic acids were obtained in moderate to excellent yield. As the experimental procedure including purification is simple, this method is applicable to large-scale syntheses. Copyright

(4-Piperidin-1-yl)phenyl amides: Potent and selective human β3 agonists

In search of potent and selective human β3 agonists as potential drugs for the treatment of human obesity and type II diabetes, a series of (4-piperidin-1-yl)phenyl amides was prepared and evaluated for their biological activity on the human β