79421-72-0Relevant academic research and scientific papers
A PSEUDOGUAIANOLIDE AND A HYDROXYGERANYLNEROL FROM KINGIANTHUS PARADOXUS
Bohlmann, Ferdinand,Ziesche, Juergen,Robinson, Harold,King, Robert M.
, p. 1146 - 1148 (1981)
Examination of Kingianthus paradoxus yielded kingiolide, a new pseudoguaianolide, and 20-hydroxygeranylnerol.Key Word Index- Kingianthus paradoxus; Compositae; Heliantheae; sesquiterpene lactones; pseudoguaianolide; kingiolide; 20-hydroxygeranylnerol.
Schizostatin, a potent squalene synthase inhibitor from Schizophyllum commune: Isolation, structure elucidation, and total synthesis
Tanimoto, Tatsuo,Tsujita, Yoshio,Hamano, Kiyoshi,Haruyama, Hideyuki,Kinoshita, Takeshi,Hosoya, Tsuyoshi,Kaneko, Satoru,Tago, Keiko,Kogen, Hiroshi
, p. 6301 - 6304 (1995)
The novel schizostatin (1) has been isolated as a potent inhibitor of squalene synthase. Its structure elucidation and total synthesis are described. Synthesis of the Z-isomer 12 and its biological activity are also reported.
Schizostatin, a novel squalene synthase inhibitor produced by the mushroom, Schizophyllum commune. II. Structure elucidation and total synthesis
Kogen, Hiroshi,Tago, Keiko,Kaneko, Satoru,Hamano, Kiyoshi,Onodera, Kaori,Haruyama, Hideyuki,Minagawa, Katsuhiro,Kinoshita, Takeshi,Ishikawa, Tomio,Tanimoto, Tatsuo,Tsujita, Yoshio
, p. 624 - 630 (2007/10/03)
Schizostatin (1) has been isolated as a potent and selective inhibitor of squalene synthase. Its structure has been determined using spectroscopic methods: the compound is shown to be a diterpenoid which has a trans-dicarboxylic acid moiety. Total synthesis of schizostatin (1) was achieved by the highly regio- and stereoselective coupling reaction of an allylic bromide with a barium reagent. The Z-isomer 16 was also prepared using the stereoselective syn-addition of an organocopper reagent to acetylenedicarboxylate.
